Recombinant Mouse IFN-beta Protein

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SDS-Page: Recombinant Mouse IFN-beta Protein [NBC1-27971] - 15% SDS-Page (3ug)

Product Details

Summary
Reactivity MuSpecies Glossary
Applications PAGE
Concentration
0.25 mg/ml

Order Details

Recombinant Mouse IFN-beta Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 22- 182 of Mouse IFN-beta

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MINYKQLQLQ ERTNIRKCQE LLEQLNGKIN LTYRADFKIP MEMTEKMQKS YTAFAIQEML QNVFLVFRNN FSSTGWNETI VVRLLDELHQ QTVFLKTVLE EKQEERLTWE MSSTALHLKS YYWRVQRYLK LMKYNSYAWM VVRAEIFRNF LIIRRLTRNF QN

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
IFNB1
Purity
>95% pure by SDS-PAGE
Endotoxin Note
< 1.0 EU per 1 microgram of protein (determined by LAL method)

Applications/Dilutions

Theoretical MW
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM HEPES(pH6.0), 0.5M NaCl, 10% glycerol
Preservative
No Preservative
Concentration
0.25 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Mouse IFN-beta Protein

  • Fibroblast interferon
  • IFBIFNB
  • IFF
  • IFNB1
  • IFNbeta
  • IFN-beta
  • interferon beta
  • interferon, beta 1, fibroblast
  • MGC96956

Background

Interferon beta 1, also known as IFN-beta, is produced mainly by fibroblasts and some epithelial cell types. IFN-beta is involved in the regulation of unspecific humoral immune responses and immune responses against viral infections. It also increases the expression of HLA class I antigens and blocks the expression of HLA class II antigens stimulated by IFN-gamma. Interferon beta 1 can be used for topic treatment of condylomata acuminata. Some studies suggest that Interferon beta 1 tends to prevent disease activity in patients with multiple sclerosis. Recombinant Interferon beta 1 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...  Read full blog post.

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Bioinformatics

Gene Symbol IFNB1
Entrez