IFN-beta Antibody [Unconjugated]

• Reactivity: Rt
• Applications: B/N
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

IFN-beta Antibody [Unconjugated] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant rat IFN-beta
• Specificity: Neutralizes both natural and recombinant rat interferon beta. Cross-reactivity with human interferon beta has not been tested.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: IFNB1
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Neutralization

Packaging, Storage & Formulations

• Storage: Upon receipt, this product is stable at 4°C until the expiration date listed above. After reconstitution, the contents can be safely stored at 4°C for one month or at -20°C for one year for retention of full activity.When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Add 0.02% sodium azide to prevent bacterial growth.
• Buffer: 0.5 ml Phosphate-buffered saline (PBS) + 125 mM trehalose prior to lyophilization.
• Preservative: No Preservative
• Reconstitution Instructions: Dissolve contents of the vial by injection of 0.5 ml sterile distilled water.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-beta Antibody [Unconjugated]

• Fibroblast interferon
• IFB
• IFBIFNB
• IFF
• IFNB
• IFNB1
• IFNbeta
• IFN-beta
• interferon beta
• interferon, beta 1, fibroblast
• MGC96956

Background

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

1. Ruuls, S.R. et al. (1996) J. Immunol. 157: 5721;
2. Zou, L.P. et al. 1999. Neuroscience Res. 56: 123

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFN-beta Antibody (33400-1)(1)

Publication using 33400-1

• L Hayden, T Semenoff, V Schultz, SF Merz, KJ Chapple, M Rodriguez, AE Warrington, X Shi, CS McKimmie, JM Edgar, K Thümmler, C Linington, M Pingen Lipid-specific IgMs induce antiviral responses in the CNS: implications for progressive multifocal leukoencephalopathy in multiple sclerosis Acta Neuropathol Commun, 2020-08-13;8(1):135. 2020-08-13 [PMID: 32792006] (Neutralization, Rat)

Bioinformatics

• Gene Symbol: IFNB1