IBTK Antibody [CoraFluor™ 1]

• Reactivity: Hu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: CoraFluor 1

IBTK Antibody [CoraFluor™ 1] Summary

• Description: CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
• Immunogen: The immunogen for this product maps to a region between residue 1050 and 1100 of human Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase, using the numbering given in entry NP_056340.2 (GeneID 25998).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: IBTK
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for IBTK Antibody [CoraFluor™ 1]

• Bruton agammaglobulinemia tyrosine kinase inhibitor
• BTK-binding protein
• BTKI
• DKFZP564B116
• IBtk
• inhibitor of Bruton agammaglobulinemia tyrosine kinase
• inhibitor of Bruton tyrosine kinase
• inhibitor of Bruton's tyrosine kinase
• inhibitor of Bruton's tyrosine kinase-alpha
• inhibitor of Bruton's tyrosine kinase-beta
• inhibitor of Bruton's tyrosine kinase-gamma
• KIAA1417
• MGC142256
• MGC142258
• RP1-93K22.1

Background

IBTK is encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IBTK