HVEM/TNFRSF14 Antibody

Western Blot: HVEM/TNFRSF14 Antibody [NBP1-76690] - Analysis of 125 ng of TNFRSF14 with TNFRSF14 antibody at 1 ug/mL.

Immunohistochemistry-Paraffin: HVEM/TNFRSF14 Antibody [NBP1-76690] - Mouse thymus tissue with TNFRSF14 antibody at 1 ug/ml.

Western Blot: HVEM/TNFRSF14 Antibody [NBP1-76690] - Mouse thymus tissue lysate with TNFRSF14 antibody at (A) 1 and (B) 2 u/mL.

Immunofluorescence: HVEM/TNFRSF14 Antibody [NBP1-76690] - Mouse Thymus tissue with TNFRSF14 antibody at 10 ug/mL.

• Reactivity: Hu, Mu
• Applications: WB, ELISA, IHC, IHC-P, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 1 mg/ml

HVEM/TNFRSF14 Antibody Summary

• Immunogen: Antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human TNFRSF14. The immunogen is located within amino acids 20 - 70 of TNFRSF14. Amino Acid Squence: PSCREDEYPVGSECC
• Specificity: Multiple isoforms of TNFRSF14 are known to exist.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TNFRSF14
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1 ug/ml
  • Immunohistochemistry-Paraffin 1 ug/ml
  • Immunofluorescence 10 ug/ml
• Theoretical MW: 23 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control Peptide:

  HVEM/TNFRSF14 Peptide (NBP1-76690PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for HVEM/TNFRSF14 Antibody

• ATAR
• CD270 antigen
• CD270
• CD40-like protein
• Herpes virus entry mediator A
• Herpesvirus entry mediator A
• HveA
• HVEM
• HVEMTR2HVEAATAR
• LIGHTR
• TNFRSF14
• tumor necrosis factor receptor superfamily member 14
• tumor necrosis factor receptor superfamily, member 14 (herpesvirus entrymediator)
• Tumor necrosis factor receptor-like 2
• tumor necrosis factor receptor-like gene2

Background

Tumor necrosis factor receptor (TNFR) superfamily members are defined by cysteine-rich domains in their extracellular regions that bind TNF-related ligands that share a common structural homology in their extracellular domain. TNFRSF14 was initially identified as the Herpesvirus entry mediator and upon binding to the herpes simplex virus (HSV) envelope glycoprotein D or either of its natural ligands LIGHT and lymphotoxin alpha (LT), activates the transcription factors NF-kappaB and AP-1. Activation of this signal transduction pathway in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HVEM/TNFRSF14 Antibody (NBP1-76690)(1)

Publication using NBP1-76690

• Abadpour S, Halvorsen B, Sahraoui A et al. Interleukin-22 reverses human islet dysfunction and apoptosis triggered by hyperglycemia and LIGHT J. Mol. Endocrinol. 2018 Jan 12 [PMID: 29330151] (Human)

Bioinformatics

• Gene Symbol: TNFRSF14
• Uniprot:
  • Q92956()