Human TWEAK/TNFSF12 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human TWEAK/TNFSF12 DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TNFSF12

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TWEAK/TNFSF12 DuoSet ELISA, 15 Plate

• APO3 ligand
• APO3LMGC20669
• DR3LGTWEAKAPO3/DR3 ligand
• MGC129581
• TNF-related weak inducer of apoptosis
• TNFSF12
• tumor necrosis factor (ligand) superfamily, member 12
• tumor necrosis factor ligand superfamily member 12
• TWEAK

Background

TWEAK is a type II transmembrane protein belonging to the TNF superfamily. The extracellular domains of human and mouse TWEAK share 89% amino acid sequence identity. A soluble form of TWEAK is generated from the membrane-associated molecule by proteolytic cleavage after Arg 93, suggesting that TWEAK may have long-range effects. TWEAK is expressed widely in many tissues and cells.

Publications for TWEAK/TNFSF12 (DY1090)(15)

Publications using DY1090

• A Altuna-Coy, X Ruiz-Plaza, M Alves-Sant, J Segarra-To, MR Chacón Serum Levels of the Cytokine TWEAK Are Associated with Metabolic Status in Patients with Prostate Cancer and Modulate Cancer Cell Lipid Metabolism In Vitro Cancers, 2021;13(18):. 2021 [PMID: 34572917] (Human)
• S Piantoni, F Regola, S Masneri, M Merletti, T Lowin, P Airò, A Tincani, F Franceschi, L Andreoli, G Pongratz Characterization of B- and T-Cell Compartment and B-Cell Related Factors Belonging to the TNF/TNFR Superfamily in Patients With Clinically Active Systemic Lupus Erythematosus: Baseline BAFF Serum Levels Are the Strongest Predictor of Response to Belimumab after Twelve Months of Therapy Frontiers in Pharmacology, 2021;12(0):666971. 2021 [PMID: 34093196] (Human)
• X Ruiz-Plaza, A Altuna-Coy, M Alves-Sant, J Vila-Barja, JF García-Fon, S Martínez-G, J Segarra-To, MR Chacón Liquid Biopsy-Based Exo-oncomiRNAs Can Predict Prostate Cancer Aggressiveness Cancers, 2021;13(2):. 2021 [PMID: 33440913] (Human)
• H Wang, S Wang, L Li, X Wang, C Liu, M Lu, Y Xia, Y Liu Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis Cytokine, 2021;138(0):155391. 2021 [PMID: 33302223] (Human)
• H Wang, S Wang, L Li, X Wang, C Liu, M Lu, Y Xia, Y Liu Involvement of the cytokine TWEAK in the pathogenesis of psoriasis vulgaris, pustular psoriasis, and erythrodermic psoriasis Cytokine, 2020;138(0):155391. 2020 [PMID: 33302223] (Human)
• X Ruiz-Plaza, E Rodríguez-, M Alves, A Altuna-Coy, J Lozano-Bar, M Portero-Ot, JF García-Fon, S Martínez-G, J Segarra, MR Chacón Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness J Transl Med, 2019;17(1):307. 2019 [PMID: 31500625] (Human)
• J Dereke, J Nilsson, C Nilsson, H Strevens, M Landin-Ols, M Hillman Soluble CD163 and TWEAK in early pregnancy gestational diabetes and later glucose intolerance PLoS ONE, 2019;14(5):e0216728. 2019 [PMID: 31071174] (Human)
• M Keshtkar-J, M Ouyang, M Keshtkarja, S Almed, H Li, JD Walston, R Rios, SX Leng Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults Vaccine, 2018;0(0):. 2018 [PMID: 29548604] (Human)
• IY Hwang, YS Youm, SD Cho, SW Choi, MH Bae, SJ Park, HW Kim Synovial fluid levels of TWEAK and matrix metalloproteinase 1 in patients with osteoarthritis, and associations with disease severity J Orthop Surg (Hong Kong), 2018;26(1):2309499018760. 2018 [PMID: 29486670] (Human)
• Nasar Alwahaibi Evaluation of interleukin-2, interleukin-8, and tumor necrosis factor-like weak inducer of apoptosis in hemodialysis and renal transplant patients and healthy controls Saudi J Kidney Dis Transpl, 2016;27(6):1123-1128. 2016 [PMID: 27900956] (Human)
• Sasaki Y, Shimizu Y, Suzuki Y, Horikoshi S, Tomino Y TWEAK/Fn14 system and crescent formation in IgA nephropathy. BMC Nephrol, 2015;16(0):27. 2015 [PMID: 25885587] (Human)
• Rojo-Martinez G, Maymo-Masip E, Rodriguez M, Solano E, Goday A, Soriguer F, Valdes S, Chaves F, Delgado E, Colomo N, Hernandez P, Vendrell J, Chacon M Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: results of the Di@bet.es study. PLoS ONE, 2014;9(6):e101250. 2014 [PMID: 24978196] (Human)
• Diaz-Lopez A, Bullo M, Chacon M, Estruch R, Vendrell J, Diez-Espino J, Fito M, Corella D, Salas-Salvado J Reduced circulating sTWEAK levels are associated with metabolic syndrome in elderly individuals at high cardiovascular risk. Cardiovasc Diabetol, 2014;13(0):51. 2014 [PMID: 24565471] (Human)
• Gaudineau B, Fougere M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S Lipocalin 2, the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion. J Cell Sci, 2012;125(0):4475-86. 2012 [PMID: 22767506] (Human)
• Chen T, Guo ZP, Li MM, Li JY, Jiao XY, Zhang YH, Liu HJ Tumour necrosis factor-like weak inducer of apoptosis (TWEAK), an important mediator of endothelial inflammation, is associated with the pathogenesis of Henoch-Schonlein purpura. Clin. Exp. Immunol., 2011;166(1):64-71. 2011 [PMID: 21762126] (Human)

Bioinformatics

• Gene Symbol: TNFSF12