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This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human Phospho-VEGFR3/Flt-4 DuoSet IC ELISA, 2 Plate
fms-related tyrosine kinase 4
soluble VEGFR3 variant 1
soluble VEGFR3 variant 2
soluble VEGFR3 variant 3
Tyrosine-protein kinase receptor FLT4
vascular endothelial growth factor receptor 3
VEGFR3Fms-like tyrosine kinase 4
VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.