VEGFR3/Flt-4 Products

Description

FLT4, a VEGF Receptor type protein kinase, is an endothelial cell-specific receptor. Binding of the extracellular domain of FLT4 to the vascular endothelial growth factor-related protein VEGF-C stimulates tyrosine phosphorylation and mitogenesis of endothelial cells. FLT4 (-/-) mice have been shown to have defective blood vessel development in early embryos and to experience cardiovascular failure at embryonic day 9.5. A mutation in the FLT4 gene has been implicated in human hereditary lymphedema type I. Similarly, a mutation in the conserved catalytic domain of FLT4, in close proximity to the FLT4 mutations in human primary lymphedema, has been linked to the Chy mouse mutant.

Bioinformatics

Entrez	114110 Rat 14257 Mouse 2324 Human
Uniprot	NM_002020 Human NP_002011 Human NP_891555 Human P35916 Human P35917 Mouse Q5SU94 Mouse
Product By Gene ID	2324
Alternate Names	EC 2.7.10 EC 2.7.10.1 FLT-4 fms-related tyrosine kinase 4 LMPH1A PCLFLT41 soluble VEGFR3 variant 1 soluble VEGFR3 variant 2 soluble VEGFR3 variant 3 Tyrosine-protein kinase receptor FLT4 vascular endothelial growth factor receptor 3 VEGFR-3 VEGFR3Fms-like tyrosine kinase 4

Research Areas for VEGFR3/Flt-4

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Hypoxia
Protein Kinase