Human Kallikrein 3/PSA DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Kallikrein 3/PSA DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: KLK3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Kallikrein 3/PSA DuoSet ELISA, 15 Plate

• APS seminin
• EC 3.4.21
• EC 3.4.21.77
• Gamma-seminoprotein
• hK3
• Kallikrein 3
• kallikrein 3, (prostate specific antigen)
• Kallikrein-3
• kallikrein-related peptidase 3
• KLK2A1
• KLK3
• P-30 antigen
• prostate specific antigen
• prostate-specific antigen
• PSA semenogelase
• PSA
• Semenogelase
• Seminin

Background

The human tissue kallikrein (KLK) gene family contains 15 members that play important roles in cancer. Notably, kallikrein-1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. Kallikrein-3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. Kallikrein-4 is specifically expressed in the prostate and over-expressed in prostate cancer. Kallikrein-5 is widely expressed but found at high levels in skin, breast, brain and testis; over-expression is an indicator of poor prognosis in ovarian cancer. Kallikrein-8 is expressed in the brain and is a novel marker of ovarian and cervical cancer.

Human plasma kallikrein, a serine protease, is synthesized in the liver and circulates in the plasma bound to high molecular weight (HMW) kininogen or as a free zymogen. Once activated by its physiological activator, coagulation factor XII, it displays endopeptidase activity towards peptide bonds after arginine (preferred) and lysine. It cleaves HMW kininogen, its major physiological substrate, to release the potent vasodilator peptide bradykinin. It is also able to cleave a number of inactive precursor proteins to generate active products, such as plasminogen and prourokinase.

Publications for Kallikrein 3/PSA (DY1344)(6)

Publications using DY1344

• Padmyastuti, A;Sarmiento, MG;Dib, M;Ehrhardt, J;Schoon, J;Somova, M;Burchardt, M;Roennau, C;Pinto, PC; Microfluidic-based prostate cancer model for investigating the secretion of prostate-specific antigen and microRNAs in vitro Scientific reports 2023-07-19 [PMID: 37468746] (Human)
• SM Hughes, CN Levy, FL Calienes, KA Martinez, S Selke, K Tapia, BH Chohan, L Oluoch, C Kiptinness, A Wald, M Ghosh, L Hardy, K Ngure, NR Mugo, F Hladik, AC Roxby Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis Elife, 2022-10-25;11(0):. 2022-10-25 [PMID: 36281966] (Human)
• SM Hughes, CN Levy, R Katz, EM Lokken, MN Anahtar, MB Hall, F Bradley, PE Castle, V Cortez, GF Doncel, R Fichorova, PL Fidel, KR Fowke, SC Francis, M Ghosh, LY Hwang, M Jais, V Jespers, V Joag, R Kaul, J Kyongo, T Lahey, H Li, J Makinde, LR McKinnon, AB Moscicki, RM Novak, MV Patel, I Sriprasert, AR Thurman, S Yegorov, NR Mugo, AC Roxby, E Micks, F Hladik, Consortium Changes in concentrations of cervicovaginal immune mediators across the menstrual cycle: a systematic review and meta-analysis of individual patient data Bmc Medicine, 2022-10-05;20(1):353. 2022-10-05 [PMID: 36195867] (Human)
• ET Choto, T Mduluza, MJ Chimbari Interleukin-13 rs1800925/-1112C/T promoter single nucleotide polymorphism variant linked to anti-schistosomiasis in adult males in Murehwa District, Zimbabwe PLoS ONE, 2021-05-28;16(5):e0252220. 2021-05-28 [PMID: 34048465] (Human)
• ET Choto, T Mduluza, F Mutapi, MJ Chimbari Association of schistosomiasis and risk of prostate cancer development in residents of Murehwa rural community, Zimbabwe Infect Agent Cancer, 2020-10-06;15(0):59. 2020-10-06 [PMID: 33042215] (Human)
• Gozal D, Jortani S, Snow AB, Kheirandish-Gozal L, Bhattacharjee R, Kim J, Capdevila OS Two-dimensional differential in-gel electrophoresis proteomic approaches reveal urine candidate biomarkers in pediatric obstructive sleep apnea. Am. J. Respir. Crit. Care Med., 2009-09-24;180(12):1253-61. 2009-09-24 [PMID: 19797158] (Human)

FAQs for Kallikrein 3/PSA (DY1344). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: KLK3