IL-18 BPa/IL18BP Products

Description

IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).

Bioinformatics

Entrez	10068 Human
Uniprot	AAD17190 Human AAH44215 Human NM_001039659 Human NM_173042 Human NP_001034749 Human NP_001138529 Human
Product By Gene ID	10068
Alternate Names	IL-18BP IL18BPa interleukin 18 binding protein interleukin-18-binding protein MC51L-53L-54L homolog gene product Tadekinig-alfa tadekinig-alfa

Research Areas for IL-18 BPa/IL18BP

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology
Innate Immunity