IL-18 BPa/IL18BP Products

Antibodies
IL-18 BPa/IL18BP Antibody [Un ...
IL-18 BPa/IL18BP Antibody [Unconju...
AF119
Species: Hu
Applications: WB, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
IL-18 BPa/IL18BP Antibody
IL-18 BPa/IL18BP Antibody
NB200-201
Species: Hu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
IL-18 BPa/IL18BP Antibody (13 ...
IL-18 BPa/IL18BP Antibody (136031)...
MAB1192
Species: Hu
Applications: ELISA(Cap)
Host: Mouse Monoclonal
ELISA Kits
IL-18 BPa/IL18BP ELISA Kit [B ...
IL-18 BPa/IL18BP ELISA Kit [Biotin]
KA1735
Species: Hu
Lysates
IL-18 BPa/IL18BP Overexpressi ...
IL-18 BPa/IL18BP Overexpression Ly...
NBP2-08582
Applications: WB
IL-18 BPa/IL18BP Overexpressi ...
IL-18 BPa/IL18BP Overexpression Ly...
NBP2-09206
Applications: WB
IL-18 BPa/IL18BP Overexpressi ...
IL-18 BPa/IL18BP Overexpression Ly...
NBL1-11920
Applications: WB
Proteins
IL-18 BPa/IL18BP Recombinant ...
IL-18 BPa/IL18BP Recombinant Prote...
NBP2-38481PEP
Species: Hu
Applications: AC
IL-18 BPa/IL18BP Recombinant ...
IL-18 BPa/IL18BP Recombinant Protein
NBP2-23150
Species: Hu
Applications: PAGE
IL-18 BPa/IL18BP Recombinant ...
IL-18 BPa/IL18BP Recombinant Protein
NBP2-53056
Species: Hu
Applications: PAGE
RNAi
IL-18 BPa/IL18BP RNAi
IL-18 BPa/IL18BP RNAi
H00010068-R01
Species: Hu
Applications: RNAi, RNAi SP
IL-18 BPa/IL18BP RNAi
IL-18 BPa/IL18BP RNAi
H00010068-R03
Species: Hu
Applications: RNAi, RNAi SP
IL-18 BPa/IL18BP RNAi
IL-18 BPa/IL18BP RNAi
H00010068-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

IL-18BP which binds to IL-18, also known as interferon-gamma inducing factor (IGIF) which is a pro-inflammatory cytokine that belongs to the IL-1 family (1). IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases (2). Interleukin-18 binding protein (IL18-BP) is an inhibitor of the pro-inflammatory cytokine IL18. The recombinant forms of IL18BP did not exhibit species specificity and prevented interleukin-18 binding to its receptor. In addition, they inhibited interleukine-18 dependent IFN-gamma production from KG-1 cells effectively. These results suggest that the interleukin-18 binding protein may possess interleukine-18 antagonist activity (3). IL-18 plays an important role in host defense against microbial pathogens. Many poxviruses encode homologous IL-18BP that neutralizes IL-18 activity. Data show that IL-18BP prevents IL-18 from binding to IL-18R by interacting with three residues that are part of the binding site for IL-18Ralpha (4).

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 10068
Alternate Names
  • Tadekinig-alfa
  • tadekinig-alfa
  • IL-18BP
  • MC51L-53L-54L homolog gene product
  • IL18BPa
  • interleukin-18-binding protein
  • interleukin 18 binding protein

Pathways for IL-18 BPa/IL18BP

View related products by pathway and learn more about each of the pathways below.

Pathogenesis
Immune Response
Mrna Splicing
Phagocytosis
Virulence
Secretion

Research Areas for IL-18 BPa/IL18BP

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology
Innate Immunity

PTMs for IL-18 BPa/IL18BP

Learn more about PTMs related to IL-18 BPa/IL18BP.

Cleavage
Phosphorylation

Bioinformatics Tool for IL-18 BPa/IL18BP

Discover related pathways, diseases and genes to IL-18 BPa/IL18BP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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