Human IL-11 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-11 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL11

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-11 DuoSet ELISA, 15 Plate

• Adipogenesis inhibitory factor
• AGIF
• AGIFoprelvekin
• IL11
• IL-11
• IL-11Oprelvekin
• interleukin 11
• interleukin-11
• Oprelvekin

Background

Interleukin-11, also known as AGIF, is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27, and IL-31. It is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts. It is found in the plasma mainly during inflammation, and is considered to be primarily anti-inflammatory. It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine. It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. IL-11 signals through a receptor complex that contains IL-11 R alpha and gp130. A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface or inhibit cell surface IL-11 R alpha/gp130 signaling.

Publications for IL-11 (DY218)(18)

Publications using DY218

• Min, S;Than, N;Shin, YC;Ertugral, EG;Kothapalli, CR;Awoniyi, O;Kim, HJ; Mechanostimulatory cues determine intestinal fibroblast fate and profibrotic remodeling in a physiodynamic human gut-on-a-chip bioRxiv : the preprint server for biology 2025-06-11 [PMID: 40661399] (Human)
• Xu, T;Huang, J;Lin, J;Liu, Y;Wang, Y;Shen, W;He, J;Chen, S;Zhu, X;Que, Y;Hu, M;Chen, Y;Cheng, L;He, H;Liu, X;Liu, S; Site-specific immunoglobulin G N-glycosylation is associated with gastric cancer progression BMC cancer 2025-02-07 [PMID: 39920693] (Human)
• Lokau, J;Bollmann, M;Garbers, Y;Feist, E;Lohmann, CH;Bertrand, J;Garbers, C; Transforming growth factor beta induces interleukin-11 expression in osteoarthritis Cytokine 2025-01-28 [PMID: 39879889] (Human)
• Shepelkova, GS;Evstifeev, VV;Berezovskiy, YS;Ergeshova, AE;Tarasov, RV;Bagirov, MA;Yeremeev, VV; Characteristics of Pulmonary Inflammation in Patients with Different Forms of Active Tuberculosis International journal of molecular sciences 2024-11-02 [PMID: 39519346] (Human)
• Singh, A;Cho, WJ;Pulimamidi, VK;Mittal, SK;Chauhan, SK; Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing Investigative ophthalmology & visual science 2023-11-01 [PMID: 37910094] (Mouse)
• MG Connor, TMN Camarasa, E Patey, O Rasid, L Barrio, CM Weight, DP Miller, RS Heyderman, RJ Lamont, J Enninga, MA Hamon The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae Nature Microbiology, 2020-12-21;0(0):. 2020-12-21 [PMID: 33349663] (Human)
• Z Kargarpour, J Nasirzade, L Panahipour, RJ Miron, R Gruber Relative Centrifugal Force (RCF; G-Force) Affects the Distribution of TGF-&beta in PRF Membranes Produced Using Horizontal Centrifugation Int J Mol Sci, 2020-10-15;21(20):. 2020-10-15 [PMID: 33076376] (Human)
• S Alarifi, S Alkahtani, AA Al-Qahtani, C Stournaras, G Sourvinos Induction of interleukin-11 mediated by RhoA GTPase during human cytomegalovirus lytic infection Cell. Signal., 2020-03-09;70(0):109599. 2020-03-09 [PMID: 32165237] (Human)
• D Brünnert, I Shekhawat, KR Chahar, J Ehrhardt, J Pandey, JK Yadav, M Zygmunt, P Goyal Thrombin stimulates gene expression and secretion of IL-11 via protease-activated receptor-1 and regulates extravillous trophoblast cell migration J. Reprod. Immunol., 2019-03-09;132(0):35-41. 2019-03-09 [PMID: 30903857] (Human)
• KLR Gustafsson, T Renné, C Söderberg-, LM Butler Human cytomegalovirus replication induces endothelial cell interleukin-11 Cytokine, 2018-05-25;0(0):. 2018-05-25 [PMID: 29807687] (Human)
• S Elbitar, D Susan-Resi, Y Ghaleb, P El Khoury, G Peloso, N Stitziel, JP Rabès, V Carreau, J Hamelin, A Ben-Djoudi, E Bruckert, C Boileau, NG Seidah, M Varret, M Abifadel New Sequencing technologies help revealing unexpected mutations in Autosomal Dominant Hypercholesterolemia Sci Rep, 2018-01-31;8(1):1943. 2018-01-31 [PMID: 29386597] (Human)
• Hoffmann F, Hofereiter J, Rubsamen H, Melms J, Schwarz S, Faber H, Weber P, Putz B, Loleit V, Weber F, Hohlfeld R, Meinl E, Krumbholz M Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation, 2015-09-30;12(0):184. 2015-09-30 [PMID: 26419927] (Human)
• Zhang X, Tao Y, Chopra M, Ahn M, Marcus K, Choudhary N, Zhu H, Markovic-Plese S Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing-remitting multiple sclerosis. J Immunol, 2013-11-06;191(12):5867-74. 2013-11-06 [PMID: 24198283] (Human)
• Ramani V, Sanderson R Chemotherapy stimulates syndecan-1 shedding: a potentially negative effect of treatment that may promote tumor relapse. Matrix Biol, 2013-10-18;35(0):215-22. 2013-10-18 [PMID: 24145151] (Human)
• Pollari S, Leivonen SK, Perälä M, Fey V, Kakonen SM, Kallioniemi O Identification of microRNAs inhibiting TGF-beta-induced IL-11 production in bone metastatic breast cancer cells. PLoS ONE, 2012-05-21;7(5):e37361. 2012-05-21 [PMID: 22629385] (Human)
• Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol, 2011-12-21;5(2):140-9. 2011-12-21 [PMID: 22189956] (Human)
• Ramani VC, Yang Y, Ren Y Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity. J. Biol. Chem., 2010-12-03;286(8):6490-9. 2010-12-03 [PMID: 21131364] (Human)
• Potapova IA, Gaudette GR, Brink PR, Robinson RB, Rosen MR, Cohen IS, Doronin SV Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro. Stem Cells, 2007-03-29;25(7):1761-8. 2007-03-29 [PMID: 17395769] (Human)

FAQs for IL-11 (DY218). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: IL11