Human Gas1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Gas1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: GAS1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Gas1 DuoSet ELISA, 15 Plate

• Gas1
• GAS-1
• growth arrest-specific 1
• Growth arrest-specific gene-1
• growth arrest-specific protein 1

Background

The growth arrest-specific genes are related by their induction following cellular stress. Gas1 is a GPI-linked membrane glycoprotein that blocks entry to S phase cell cycle. Gas1 inhibits cell proliferation, protects endothelial cells from apoptosis, and promotes excitotoxic neuronal death. Gas6 is a vitamin K-dependent protein with a gamma-carboxylated amino terminus (Gla domain), four EGF-like repeats, and C-terminal globulin-like domains. Gas6 is a ligand for the Axl, Dtk, and Mer tyrosine kinase receptors. Gas6 is mitogenic and anti-apoptotic for some cell types and also promotes cell adhesion.

Publications for Gas1 (DY2636)(4)

Publications using DY2636

• Joseph T Clark, David A Christian, Jodi A Gullicksrud, Joseph A Perry, Jeongho Park, Maxime Jacquet et al. IL-33 promotes innate lymphoid cell-dependent IFN-gamma production required for innate immunity to Toxoplasma gondii eLife 2021-04-30 [PMID: 33929319] (Transgenic Mouse)
• L Daniel-Gar, P Vergara, A Navarrete, RO González, J Segovia Simultaneous Treatment with Soluble Forms of GAS1 and PTEN Reduces Invasiveness and Induces Death of Pancreatic Cancer Cells Onco Targets Ther, 2020-11-17;13(0):11769-11779. 2020-11-17 [PMID: 33235464] (Human)
• C Göpfert, N Andreas, F Weber, N Häfner, T Yakovleva, M Gaestel, T Kamradt, S Drube The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells J. Immunol., 2017-12-29;0(0):. 2017-12-29 [PMID: 29288203] (Mouse)
• van Roeyen C, Zok S, Pruessmeyer J, Boor P, Nagayama Y, Fleckenstein S, Cohen C, Eitner F, Grone H, Ostendorf T, Ludwig A, Floege J Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation. Kidney Int, 2012-12-19;83(2):251-63. 2012-12-19 [PMID: 23254899] (Human)

Bioinformatics

• Gene Symbol: GAS1