Human Cystatin C DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Cystatin C DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CST3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Cystatin C DuoSet ELISA, 15 Plate

• ARMD11
• bA218C14.4 (cystatin C)
• CST3
• cystatin 3
• cystatin C (amyloid angiopathy and cerebral hemorrhage)
• Cystatin C
• cystatin-3
• cystatin-C
• Gamma-trace
• MGC117328
• Neuroendocrine basic polypeptide
• Post-gamma-globulin

Background

Cystatin C is a secreted cysteine protease inhibitor that inhibits Cathepsins B, H, K, L, and S. Cystatin C serum concentration correlates closely to the glomerular filtration rate (GFR); elevated levels are associated with coronary artery and cardiovascular disease risk. Dysregulation of Cystatin C can modulate tumor growth and metastasis. In humans, the L68Q variant forms dimers and oligomers more easily than wild type protein and is the cause for hereditary Cystatin C amyloid angiopathy.

Publications for Cystatin C (DY1196)(8)

Publications using DY1196

• Lablad, Y;Vanhomwegen, C;De Prez, E;Antoine, MH;Hasan, S;Baudoux, T;Nortier, J; Longitudinal Follow-Up of Serum and Urine Biomarkers Indicative of COVID-19-Associated Acute Kidney Injury: Diagnostic and Prognostic Impacts International journal of molecular sciences 2023-11-18 [PMID: 38003685] (Human)
• BV Vu, R Lei, C Mohan, K Kourentzi, RC Willson Flash Characterization of Smartphones Used in Point-of-Care Diagnostics Biosensors, 2022-11-22;12(12):. 2022-11-22 [PMID: 36551027] (Human)
• S Denamur, T Chazeirat, M Maszota-Zi, RR Vivès, A Saidi, F Zhang, RJ Linhardt, F Labarthe, SA Samsonov, G Lalmanach, F Lecaille Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: Putative consequences in mucopolysaccharidosis Carbohydrate polymers, 2022-06-18;293(0):119734. 2022-06-18 [PMID: 35798429] (Human)
• AL Conroy, MT Hawkes, R Elphinston, RO Opoka, S Namasopo, C Miller, CC John, KC Kain Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria Malar. J., 2018-02-15;17(1):82. 2018-02-15 [PMID: 29448936] (Human)
• Peters B, Hall M, Liu X, Neugut Y, Pilsner J, Levy D, Ilievski V, Slavkovich V, Islam T, Factor-Litvak P, Graziano J, Gamble M Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh. PLoS ONE, 2014-12-01;9(12):U1429. 2014-12-01 [PMID: 25438247] (Human)
• Kasabova M, Joulin-Giet A, Lecaille F, Gilmore B, Marchand-Adam S, Saidi A, Lalmanach G Regulation of TGF-beta1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C. J Biol Chem, 2014-04-30;289(23):16239-51. 2014-04-30 [PMID: 24790080] (Human)
• Lv B, Lindholt J, Cheng X, Wang J, Shi G Plasma cathepsin S and cystatin C levels and risk of abdominal aortic aneurysm: a randomized population-based study. PLoS ONE, 2012-07-23;7(7):e41813. 2012-07-23 [PMID: 22844527] (Human)
• Kagedan D, Lecker I, Batruch I Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry. Clin Proteomics, 2012-02-06;9(1):2. 2012-02-06 [PMID: 22309592] (Human)

FAQs for Cystatin C (DY1196). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: CST3