Human Cystatin C DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Cystatin C DuoSet ELISA, 15 Plate Summary

• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CST3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Cystatin C DuoSet ELISA, 15 Plate

• ARMD11
• bA218C14.4 (cystatin C)
• CST3
• cystatin 3
• cystatin C (amyloid angiopathy and cerebral hemorrhage)
• Cystatin C
• cystatin-3
• cystatin-C
• Gamma-trace
• MGC117328
• Neuroendocrine basic polypeptide
• Post-gamma-globulin

Background

Cystatin C is a secreted cysteine protease inhibitor that inhibits Cathepsins B, H, K, L, and S. Cystatin C serum concentration correlates closely to the glomerular filtration rate (GFR); elevated levels are associated with coronary artery and cardiovascular disease risk. Dysregulation of Cystatin C can modulate tumor growth and metastasis. In humans, the L68Q variant forms dimers and oligomers more easily than wild type protein and is the cause for hereditary Cystatin C amyloid angiopathy.

Publications for Cystatin C (DY1196)(6)

Publications using DY1196

• S Denamur, T Chazeirat, M Maszota-Zi, RR Vivès, A Saidi, F Zhang, RJ Linhardt, F Labarthe, SA Samsonov, G Lalmanach, F Lecaille Binding of heparan sulfate to human cystatin C modulates inhibition of cathepsin L: Putative consequences in mucopolysaccharidosis Carbohydrate polymers, 2022;293(0):119734. 2022 [PMID: 35798429] (Human)
• AL Conroy, MT Hawkes, R Elphinston, RO Opoka, S Namasopo, C Miller, CC John, KC Kain Chitinase-3-like 1 is a biomarker of acute kidney injury and mortality in paediatric severe malaria Malar. J., 2018;17(1):82. 2018 [PMID: 29448936] (Human)
• Peters B, Hall M, Liu X, Neugut Y, Pilsner J, Levy D, Ilievski V, Slavkovich V, Islam T, Factor-Litvak P, Graziano J, Gamble M Creatinine, arsenic metabolism, and renal function in an arsenic-exposed population in Bangladesh. PLoS ONE, 2014;9(12):U1429. 2014 [PMID: 25438247] (Human)
• Kasabova M, Joulin-Giet A, Lecaille F, Gilmore B, Marchand-Adam S, Saidi A, Lalmanach G Regulation of TGF-beta1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C. J Biol Chem, 2014;289(23):16239-51. 2014 [PMID: 24790080] (Human)
• Lv B, Lindholt J, Cheng X, Wang J, Shi G Plasma cathepsin S and cystatin C levels and risk of abdominal aortic aneurysm: a randomized population-based study. PLoS ONE, 2012;7(7):e41813. 2012 [PMID: 22844527] (Human)
• Kagedan D, Lecker I, Batruch I Characterization of the seminal plasma proteome in men with prostatitis by mass spectrometry. Clin Proteomics, 2012;9(1):2. 2012 [PMID: 22309592] (Human)

Bioinformatics

• Gene Symbol: CST3