Human BMP-6 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human BMP-6 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: BMP6

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human BMP-6 DuoSet ELISA, 15 Plate

• BMP6
• BMP-6
• bone morphogenetic protein 6
• vegetal related growth factor (TGFB-related)
• vegetal-related (TGFB related) cytokine
• VG-1-R
• VG-1-related protein
• Vg1-related sequence
• VGR
• VGR1
• Vgr-1

Background

BMPs are secreted signaling molecules that comprise a subfamily of the TGF-beta superfamily and were originally identified as regulators of cartilage and bone formation. There are at least 20 structurally and functionally related BMPs, most of which play roles in embryogenesis and morphogenesis of various tissues and organs. Biologically active BMPs are usually homodimers containing a characteristic cysteine knot structure. Heterodimers, BMP-2/BMP-7 and BMP-4/BMP-7 have also been suggested to exist and function in vivo. They are more potent inducers of bone formation than their respective homodimers. In addition, heterodimers, but not homodimers, are ventral mesoderm inducers. Heterodimer activity may be mediated by a different or additional receptor subtype.

Decapentaplegic (Dpp) is one of at least five TGF-beta superfamily ligands identified in the Drosophila genome. Dpp, a functional ortholog of mammalian BMP-2 and BMP-4, is a morphogen and plays an essential role in Drosophila development. Dpp regulates embryonic dorsal-ventral polarity and is required for gut morphogenesis and outgrowth and patterning of imaginal disks.

Publications for BMP-6 (DY507)(7)

Publications using DY507

• JP Lapuente, A Blázquez-M, J Marco-Brua, G Gómez, P Desportes, J Sanz, P Fernández, M García-Gil, F Bermejo, JV San Martín, A Algaba, JC De Gregori, D Lapuente, A De Gregori, B Lapuente, MV Andrés, A Anel Cytokine Profile and Anti-Inflammatory Activity of a Standardized Conditioned Medium Obtained by Coculture of Monocytes and Mesenchymal Stromal Cells (PRS CK STORM) Biomolecules, 2022-03-31;12(4):. 2022-03-31 [PMID: 35454123] (Human)
• LD Loozen, A Vanderstee, AH Kragten, FC Öner, WJ Dhert, MC Kruyt, J Alblas Bone formation by heterodimers through non-viral gene delivery of BMP-2/6 and BMP-2/7 Eur Cell Mater, 2018-03-28;35(0):195-208. 2018-03-28 [PMID: 29589649] (Goat)
• Human iPSCs Differentiate Into Functional MSCs and Repair Bone Defects Stem Cells Transl Med, 2016-07-11;0(0):. 2016-07-11 [PMID: 27400789] (Human)
• Seeger P, Bosisio D, Parolini S, Badolato R, Gismondi A, Santoni A, Sozzani S Activin A as a mediator of NK-dendritic cell functional interactions. J Immunol, 2014-01-06;192(3):1241-8. 2014-01-06 [PMID: 24395917] (Human)
• Lu C, Yeh T, Yeh C, Fang Y, Sung L, Lin S, Yen T, Chang Y, Hu Y Regenerating cartilages by engineered ASCs: prolonged TGF-beta3/BMP-6 expression improved articular cartilage formation and restored zonal structure. Mol Ther, 2013-07-15;22(1):186-95. 2013-07-15 [PMID: 23851345] (Rabbit)
• van Houten E, Laven J, Louwers Y, McLuskey A, Themmen A, Visser J Bone morphogenetic proteins and the polycystic ovary syndrome. J Ovarian Res, 2013-04-30;6(1):32. 2013-04-30 [PMID: 23627969] (Human)
• Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res., 2005-09-15;65(18):8274-85. 2005-09-15 [PMID: 16166304] (Human)

FAQs for BMP-6 (DY507). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: BMP6