HOX11 Antibody

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Western Blot: HOX11 Antibody [NB100-56424] - Annalysis of HOX11 in A) human, B) mouse and C) rat liver cell lysate using NB100-56424 at 1 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

HOX11 Antibody Summary

Immunogen
A peptide sequence corresponding to acids amino acids 306-318 (LQNLQPWSDDSTK) of human HOX11 was used as the immunogen.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TLX1
Purity
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-3 ug/ml

Reactivity Notes

Cross reacts with Mouse, Human and Rat. Predicted to react with Bovine, Chicken, Chimpanzee, Dog and Xenopus.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for HOX11 Antibody

  • homeo box 11 (T-cell lymphoma 3-associated breakpoint)
  • homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to DrosophilaNotch)
  • Homeobox protein Hox-11
  • HOX11T-cell leukemia, homeobox 1
  • Proto-oncogene TCL-3
  • T-cell leukemia homeobox 1
  • T-cell leukemia homeobox protein 1
  • T-cell leukemia/lymphoma protein 3
  • TCL3MGC163402

Background

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Additional HOX11 Products

Array NB100-56424

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Bioinformatics

Gene Symbol TLX1
Entrez