HOX11 Products

Antibodies
HOX11 Antibody
HOX11 Antibody
NB100-56424
Species: Hu, Mu, Rt
Applications: WB
Host: Rabbit Polyclonal
Lysates
HOX11 Overexpression Lysate ( ...
HOX11 Overexpression Lysate (Native)
NBP2-10462
Applications: WB
RNAi
HOX11 RNAi
HOX11 RNAi
H00003195-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Product By Gene ID 3195
Alternate Names
  • T-cell leukemia/lymphoma protein 3
  • T-cell leukemia homeobox protein 1
  • Proto-oncogene TCL-3
  • homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to DrosophilaNotch)
  • Homeobox protein Hox-11
  • TCL3MGC163402
  • HOX11T-cell leukemia, homeobox 1
  • homeo box 11 (T-cell lymphoma 3-associated breakpoint)
  • T-cell leukemia homeobox 1

PTMs for HOX11

Learn more about PTMs related to HOX11.

Methylation
Phosphorylation
Biotinylation
Demethylation
Cleavage
Acetylation

Bioinformatics Tool for HOX11

Discover related pathways, diseases and genes to HOX11. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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