Histamine H2R Antibody - BSA Free

Immunohistochemistry-Paraffin: Histamine H2 R Antibody [NLS1175] - Analysis of anti-HRH2 / Histamine H2 Receptor antibody with human stomach, parietal cells.

• Reactivity: Hu, Pm, Pm, Rb, Mu, Rt, Pm, Pm-Or
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Histamine H2R Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human Histamine H2R.
• Epitope: 3rd cytoplasmic domain
• Specificity: Human Histamine H2R. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (94%), Rat (94%), Orangutan (100%), Chimpanzee (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HRH2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 38 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Canine (81%), Bat (81%), Rabbit (81%), Guinea pig (81%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Histamine H2R Antibody - BSA Free

• Gastric Receptor 1
• Gastric receptor I
• H2R
• HH2R
• Histamine H2 R
• histamine H2 receptor
• Histamine H2R
• histamine receptor H2
• HRH2

Background

H2 Histamine Receptor stimulates adenylate cyclase activity and leads to the release of acids in the stomach. It is also involved in GI motility and intestinal secretion. Treatments for acid-peptic disorders are based on the inhibition of histamine H2 receptor activity. The 3'-untranslated region may be involved in differential expression. Histamine H2 receptor has been reported to be expressed in bone marrow, brain, heart, lymph node, nose, placenta, spinal cord, and stomach. An EST has been isolated from a kidney library.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Histamine H2R Antibody (NLS1175)(3)

Publications using NLS1175

• Pal S, Gashev A, Roy D Nuclear localization of histamine receptor 2 in primary human lymphatic endothelial cells Biology open 2022-07-15 [PMID: 35776777] (Immunohistochemistry-Paraffin, Rabbit)
• Pal S, Gasheva OY, Zawieja DC et al. Histamine-mediated autocrine signaling in mesenteric perilymphatic mast cells Am. J. Physiol. Regul. Integr. Comp. Physiol. 2020-01-08 [PMID: 31913658]
• Dagli M, Goksu N, Eryilmaz A et al. Expression of histamine receptors (H(1), H(2), and H(3)) in the rabbit endolymphatic sac: an immunohistochemical study. Am J Otolaryngol. 2008-01-01 [PMID: 18061827] (IHC-P, Rabbit)
  
  Details:
  Antibodies cited [IHC(paraffin), rabbit endolymphatic sac tissue]: 1. IMG-71324 (H1 receptor), Fig. 2. 2. IMG-71325 (H2 receptor), Fig. 3. 3. IMG-71328 (H3 receptor), Fig. 4.

Bioinformatics

• Gene Symbol: HRH2
• Entrez:
  • 3274(Human)