Hepsin Antibody [Alexa Fluor™ Plus 555]

• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor Plus 555

Hepsin Antibody [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human Hepsin in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Hepsin Antibody [Alexa Fluor™ Plus 555]

• EC 3.4.21
• EC 3.4.21.106
• Hepsin
• HPN
• serine protease hepsin catalytic chain
• serine protease hepsin
• TMPRSS1
• TMPRSS1serine protease hepsin non-catalytic chain
• Transmembrane protease serine 1
• transmembrane protease, serine 1

Background

Hepsin, also known as TMPRSS1, is a Type II membrane protein with an extracellular serine protease domain (1). It is most highly expressed in liver, but is also present in many other tissues, notably lung, kidney, and skeletal muscle (2). A soluble form of Hepsin lacking the transmembrane domain has been identified (3). Hepsin is capable of activating Factor VII, and may initiate blood coagulation at the cell surface (4). Hepsin is overexpressed in various human tumors, including prostate (5), and is considered to be a biomarker for prostate cancer (6).

1. Leytus, S.P. et al. (1988) Biochemistry 27:1067.
2. Tsuji, A. et al. (1991) J. Biol. Chem. 266:16948.
3. Li, Y. et al. (2005) Biomed. Biochim. Acta 1681:157.
4. Kazama, Y. et al. (1995) J. Biol. Chem. 270:66.
5. Dhanasekaran, S.M. et al. (2001) Nature 412:822.
6. Wu, Q. and Parry, G. (2007) Front. Biosci. 12:5052.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.