Human Corin DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Corin DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CORIN

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Corin DuoSet ELISA, 15 Plate

• ATC2
• atrial natriuteric peptide-converting enzyme
• Corin
• corin, serine peptidase
• EC 3.4.21
• EC 3.4.21.-
• heart specific serine proteinase
• Heart-specific serine proteinase ATC2
• MGC119742
• pro-ANP-convertase
• Pro-ANP-Converting Enzyme
• PRSC
• serine protease
• Transmembrane protease serine 10

Background

Corin is a type II transmembrane serine protease expressed predominantly in cardiomyocytes. It converts pro-atrial natriuretic peptide (pro-ANP) to ANP.

Publications for Corin (DY2209)(8)

Publications using DY2209

• Wang, H;Liu, YS;Peng, Y;Chen, W;Dong, N;Wu, Q;Pan, B;Wang, B;Guo, W; Golgi ?-Mannosidases Regulate Cell Surface N-Glycan Type and Ectodomain Shedding of the Transmembrane Protease Corin The Journal of biological chemistry 2023-09-01 [PMID: 37660903] (Human)
• NK Binder, S Beard, N de Alwis, BR Fato, TV Nguyen, TJ Kaitu'u-Li, NJ Hannan Investigating the Effects of Atrial Natriuretic Peptide on the Maternal Endothelium to Determine Potential Implications for Preeclampsia International Journal of Molecular Sciences, 2023-03-24;24(7):. 2023-03-24 [PMID: 37047162] (Human)
• SS Zaidi, RD Ward, K Ramanathan, X Yu, IP Gladysheva, GL Reed Possible Enzymatic Downregulation of the Natriuretic Peptide System in Patients with Reduced Systolic Function and Heart Failure: A Pilot Study Biomed Res Int, 2018-07-26;2018(0):7279036. 2018-07-26 [PMID: 30148170] (Human)
• Y Gu, D Thompson, J Xu, DF Lewis, JA Morgan, DB Cooper, CE McCathran, Y Wang Aberrant pro-atrial natriuretic peptide/corin/natriuretic peptide receptor signaling is present in maternal vascular endothelium in preeclampsia Pregnancy Hypertens, 2017-12-07;11(0):1-6. 2017-12-07 [PMID: 29523263] (Human)
• B Dhole, S Gupta, SK Venugopal, A Kumar Triiodothyronine stimulates VEGF expression and secretion via steroids and HIF-1? in murine Leydig cells Syst Biol Reprod Med, 2018-02-08;0(0):1-11. 2018-02-08 [PMID: 29417848] (Human)
• C Sun, L Shen, W Sha, L Zhou, D Xu, N Dong IL-1? increases urinary corin in patients with primary proteinuric kidney diseases and in 293 cells Exp Ther Med, 2017-10-30;15(1):487-493. 2017-10-30 [PMID: 29387201] (Human)
• Zhang Y, Li H, Zhou J, Wang A, Yang J, Wang C, Liu M, Zhou T, Zhu L, Zhang Y, Dong N, Wu Q A corin variant identified in hypertensive patients that alters cytoplasmic tail and reduces cell surface expression and activity. Sci Rep, 2014-12-09;4(0):7378. 2014-12-09 [PMID: 25488193] (Human)
• Ibebuogu UN, Gladysheva IP, Houng AK Decompensated heart failure is associated with reduced corin levels and decreased cleavage of pro-atrial natriuretic peptide. Circ Heart Fail, 2011-01-07;4(2):114-20. 2011-01-07 [PMID: 21216831] (Human)

FAQs for Corin (DY2209). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: CORIN