Heparan Sulfate 6-O-Sulfotransferase 1/HS6ST1 Antibody (584308) [Alexa Fluor® 488]

• Reactivity: Hu
• Applications: IHC
• Clone: 584308
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Heparan Sulfate 6-O-Sulfotransferase 1/HS6ST1 Antibody (584308) [Alexa Fluor® 488] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Heparan Sulfate 6-O-Sulfotransferase 1/HS6ST1
  Pro38-Trp411
  Accession # O60243
• Specificity: Detects human Heparan Sulfate 6-O-Sulfotransferase 1/HS6ST1 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Heparan Sulfate 6-O-Sulfotransferase 1/HS6ST1 Antibody (584308) [Alexa Fluor® 488]

• DKFZp547H098
• EC 2.8.2
• EC 2.8.2.-
• FLJ25392
• heparan sulfate 6-O-sulfotransferase 1
• heparan-sulfate 6-sulfotransferase
• HS6ST1
• HS6ST-1
• HS6STheparan-sulfate 6-O-sulfotransferase 1
• MGC116899
• MGC116901

Background

Heparan Sulfate is a highly sulfated polysaccharide that can be found on cell surface and extracellular matrix. It is usually covalently attached to a protein core as the glycan component of a proteoglycan. Heparan Sulfate interacts with a variety of proteins, such as growth factors, protease inhibitors, cytokines, lipoprotein lipase and viral envelope proteins, thus plays roles from cell growth, cell differentiation, cell motility, blood coagulation, lipid metabolism to viral infection (1, 2). Heparan Sulfate consists of repeating residues of uronic acid and N‑acetylglucosamine. The uronic acid residues can be sulfated at 2-O position by Heparan Sulfate 2-O Sulfotransferase (HS2ST). The N‑acetylglucosamine residues can be sulfated at N-, 3-O, and 6-O positions by N‑deacetylase/N‑sulfotransferases (NDSTs), Heparan Sulfate 3-O and 6-O sulfotransferases (HS3STs and HS6STs) respectively. However, the reactions catalyzed by these sulfotransferases are normally incomplete on the whole chain of Heparan Sulfate. As a result, Heparan Sulfate displays enormous sequence diversity that allows it to interact with a wide spectrum of proteins differently. Among three HS6STs, HS6ST1 is the first to be cloned (3). Mice deficient of the HS6ST1 homologue gene showed embryonic lethality (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.