HDAC6 Antibody [DyLight 488]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications ICC/IF, IHC (-), WB (-)
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 488

HDAC6 Antibody [DyLight 488] Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human HDAC6 protein (between residues 1175-1215) [UniProt Q9UBN7]
Localization
Nucleus. Cytoplasm. Note: It is cytoplasmic when associated with microtubules.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HDAC6
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:100
Application Notes
This HDAC6 antibody is useful for Immunocytochemistry/Immunofluorescence. In ICC/IF, nuclear staining was observed in HeLa cells. Antibody did not work in IHC-paraffin embedded sections in mouse intestine or Western Blot.

Reactivity Notes

Human and mouse. Mouse data from customer feedback.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for HDAC6 Antibody [DyLight 488]

  • EC 3.5.1.98
  • HD6FLJ16239
  • histone deacetylase 6
  • JM21
  • KIAA0901

Background

Histone deacetylase 6 (HDAC-6, HD6, and JM21) is a class II histone deacetylase/AcuC/AphA family member. HDAC-6 primarily functions to alter chromosome structure, regulate transcription factor access to DNA, and deacetylate the lysine residues on the N-terminal region of histones. The deacetylase activity, in turn, has a role in the degradation of misfolded proteins by autophagy (PMID: 21235576). The HDAC-6 protein contains two catalytic domains that function independently of each other and plays an important role in cell motility (microtubule dependent) by the deacetylation of tubulin. Research involving HDAC-6 includes cancer development and progression, Parkinson's disease, and epigenetics (PMID: 21455583, 21235576).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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LAMP2: Protector of the lysosome
LAMP2 belongs to the family of membrane glycoproteins who confer selectins with carbohydrate ligands. LAMP2 has been implicated in tumor cell metastasis, as well as overall protection, maintenance, and adhesion of the lysosome. It appears that LAMP2 m...  Read full blog post.

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Bioinformatics

Gene Symbol HDAC6