Gremlin 1 Antibody (4C2) - Azide and BSA Free

ELISA: Gremlin 1 Antibody (4C2) [H00026585-M04] - Detection limit for recombinant GST tagged GREM1 is approximately 3ng/ml as a capture antibody.

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 4C2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

Gremlin 1 Antibody (4C2) - Azide and BSA Free Summary

• Immunogen: GREM1 (NP_037504, 75 a.a. ~ 184 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. ESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
• Specificity: GREM1 - gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: GREM1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Western Blot 1:500
• Application Notes: Antibody reactive against recombinant protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control.

Reactivity Notes

Other species not tested.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Gremlin 1 Antibody (4C2) - Azide and BSA Free

• Cell proliferation-inducing gene 2 protein
• CKTSF1B1gremlin 1, cysteine knot superfamily, homolog
• Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
• DAN domain family member 2
• DAND2
• DAND2GREMLIN
• Down-regulated in Mos-transformed cells protein
• DRM
• DRMMGC126660
• GREM1
• gremlin 1
• gremlin 1-like protein
• Gremlin
• gremlin-1
• IHG-2
• Increased in high glucose protein 2
• increased in high glucose-2
• proliferation-inducing gene 2

Background

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GREM1
• Entrez:
  • 26585(Human)
• OMIM:
  • 603054(Human)
• Uniprot:
  • NP_037504(Human)