Gremlin 1 Antibody (155606) [CoraFluor™ 1]

• Reactivity: Mu
• Applications: ELISA, ELISA(Cap), ELISA(Det)
• Clone: 155606
• Clonality: Monoclonal
• Host: Rat
• Conjugate: CoraFluor 1

Gremlin 1 Antibody (155606) [CoraFluor™ 1] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Gremlin
  Lys25-Asp184
  Accession # O70326
• Specificity: Detects mouse Gremlin in ELISAs. In sandwich immunoassays, no cross-reactivity or interference with recombinant chicken Caronte, recombinant human (rh) Cerberus, rhCOCO, rhGremlin, rhBMP-2, rhBMP-4, recombinant mouse (rm) DAN, rmPRDC, rmSlit1, rmSlit2, or rmBMP-4 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: GREM1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Gremlin 1 Antibody (155606) [CoraFluor™ 1]

• Cell proliferation-inducing gene 2 protein
• CKTSF1B1gremlin 1, cysteine knot superfamily, homolog
• Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
• DAN domain family member 2
• DAND2
• DAND2GREMLIN
• Down-regulated in Mos-transformed cells protein
• DRM
• DRMMGC126660
• GREM1
• gremlin 1
• gremlin 1-like protein
• Gremlin
• gremlin-1
• IHG-2
• Increased in high glucose protein 2
• increased in high glucose-2
• proliferation-inducing gene 2

Background

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GREM1