GR/NR3C1 Antibody (1006903) [Alexa Fluor® 350]

• Reactivity: Hu, Rt
• Applications: WB, IHC, ICC/IF
• Clone: 1006903
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 350

GR/NR3C1 Antibody (1006903) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human GR/NR3C1
  Val271-Lys777
  Accession # P04150
• Specificity: Detects human GR/NR3C1 in direct ELISAs. Detects human and rat GR/NR3C1 in Western blots.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GR/NR3C1 Antibody (1006903) [Alexa Fluor® 350]

• GCR
• glucocorticoid receptor
• GR
• GRGCCR
• GRLNuclear receptor subfamily 3 group C member 1
• NR3C1
• nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
• nuclear receptor subfamily 3, group C, member 1

Background

GR is a glucocorticoid receptor that is expressed in almost every cell in the body and regulates genes controlling development, metabolism and the immune response. The unbound receptor resides in the cytosol of the cell, but upon binding to glucocorticoids, it is translocated to the nucleus where it regulates gene transcription. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or acts to repress the expression of pro-inflammatory proteins in the cytosol. It is also involved in chromatin remodeling and plays a role in rapid mRNA degradation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • P04150()