GOSR1 Antibody [DyLight 550]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, IHC, NULL
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 550

GOSR1 Antibody [DyLight 550] Summary

• Immunogen: golgi SNAP receptor complex member 1. (Uniprot# O95249)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GOSR1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Serum
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for GOSR1 Antibody [DyLight 550]

• golgi integral membrane protein 2
• golgi SNAP receptor complex member 1,28 kDa cis-Golgi SNARE p28
• Golgi SNARE 28 kDa
• GOLIM2
• GOS28cis-golgi SNARE
• GOS-28GOS28/P28
• GOSR1
• GS28
• GS2828 kDa Golgi SNARE protein
• p28

Background

In eukaryotic cells, the Golgi apparatus receives newly synthesized proteins from the endoplasmic reticulum (ER) and delivers them after covalent modification to their destination in the cell. Although little is known about membrane-tubule-mediated transport, the molecular mechanism for vesicle-mediated transport is quite well understood, occurring through docking of SNAREs on the vesicle with those on the target membrane. (1). Transport of proteins along the exocytotic pathway is primarily achieved by vesicular intermediates. Two proteins, Golgi SNAREs of 27 kDa, GS27, and of 28 kDa, GS28 are important trafficking membrane proteins between the endoplasmic reticulum and the Golgi and between Golgi subcompartments (2). In vitro, GOS-28, A Golgi SNARE of 28 kD, is efficiently packaged into Golgi-derived vesicles, which are most likely COPI coated. Antibodies directed against GOS-28 block its ability to bind alpha-SNAP, partially inhibit transport from the cis to the medial cisternae, and do not inhibit budding of COP-coated vesicles, but do accumulate docked uncoated vesicles (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GOSR1