Glutathione Reductase Antibody

Western Blot: Glutathione Reductase Antibody [NBP2-24940] - analysis of GR (2- Glutathione reductase from S. cerevisiae) in human liver lysate using this antibody. 5 ug/ml.

Product Discontinued

Glutathione Reductase Antibody Summary

• Immunogen: Glutathione Reductase from bakers yeast (S. cerevisiae)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GSR
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5-1.0 ug/ml

Reactivity Notes

This antibody is reactive to Human, S. cerevisiae

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.2 ml PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein A purified

Alternate Names for Glutathione Reductase Antibody

• EC 1.8.1
• EC 1.8.1.7
• GLUR
• Glutathione Reductase
• glutathione reductase, mitochondrial
• GR
• GRase
• GRD1
• GSR
• HEL-752
• MGC78522

Background

Glutathione reductase (GR) is a member of pyridine nucleotide-disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione(GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+ ->2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Glutathione Reductase Antibody (NBP2-24940)(1)

Publication using NBP2-24940

• Yang SP, Yang XZ, Cao GP. Acetyl-l-carnitine prevents homocysteine-induced suppression of Nrf2/Keap1 mediated antioxidation in human lens epithelial cells. Mol Med Rep 2015-07-01 [PMID: 25776802]

Bioinformatics

• Gene Symbol: GSR