Glut4 Antibody (6H11NB) - BSA Free

Images

 
Western Blot: Glut4 Antibody (6H11NB) [NBP2-44298] - Analysis of GLUT4 [6H11BN] in partial recombinant GLUT4 protein.
Immunohistochemistry-Paraffin: Glut4 Antibody (6H11NB) [NBP2-44298] - Analysis of a FFPE tissue section of normal human skeletal muscle using 1:300 dilution of Glut4 antibody (clone 6H11NB). The antibody generated a ...read more
Western Blot: Glut4 Antibody (6H11NB) [NBP2-44298] - Analysis of human heart tissue lysate using 1:500 dilution of GLUT4 antibody [clone 6H11NB]. The antibody generated a single specific band of Glut4 at ~55 kDa ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, IHC, IHC-P
Clone
6H11NB
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Format
BSA Free
Concentration
1.0 mg/ml

Order Details

Glut4 Antibody (6H11NB) - BSA Free Summary

Immunogen
Partial recombinant human Glut4 protein (amino acids 225-288) [Uniprot: P14672]
Localization
Cell Membrane, ER Membrane, Perinuclear
Predicted Species
Mouse (94%), Rat (95%), Bovine (94%). Backed by our 100% Guarantee.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SLC2A4
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:300
  • Immunohistochemistry-Paraffin 1:200 - 1:300
  • Western Blot 1:500

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Glut4 Antibody (6H11NB) - BSA Free

  • Glut4
  • GLUT-4
  • GLUT4Glucose transporter type 4, insulin-responsive
  • insulin-responsive glucose transporter type 4
  • SLC2A4
  • solute carrier family 2 (facilitated glucose transporter), member 4
  • solute carrier family 2, facilitated glucose transporter member 4

Background

Glucose Transporter GLUT4 (SLC2A4 or GLUT4) is an insulin-sensitive glucose transporter which facilitate insulin-stimulated glucose uptake in adipose tissue, skeletal muscle and cardiac tissues (that specifically express GLUT4). GLUT4 is a 12-transmembrane domain/ multi-pass membrane protein localized in endomembrane system as well as cytoplasm near perinuclear region, and facilitates glucose transport in the direction of glucose gradient. This transporter localizes to intracellular organelles (endosomes) in unstimulated cells and translocates to the cell surface following insulin stimulation via TBC1D4 phosphorylation. Transgenic mice lacking or overexpressing GLUT4 respectively decrease or increase whole-body insulin sensitivity, suggesting its role in maintenance of glucose homeostasis, and accordingly, under obesity conditions, reduction of GLUT4 gene expression is directly related to insulin resistance development. Inflammatory cytokines produced by the adipose tissue including TNF-alpha, IL-6 etc have been related to reduce GLUT4 expression and defective GLUT4 is an underlying cause of NIDDM.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Secondary Antibodies

 

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Blogs on Glut4.

Glucose Transporter 4 (GLUT4, SLC2A4)
GLUT4 is an insulin-sensitive glucose transporter that facilitates insulin-stimulated glucose uptake in adipose tissue, skeletal muscle, and cardiac tissues that specifically express this protein. It is a twelve transmembrane domain multi-pass protein...  Read full blog post.

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Bioinformatics

Gene Symbol SLC2A4
Entrez
OMIM
Uniprot