GLP1 Antibody (4) - BSA Free

Immunohistochemistry: Glucagon Antibody (4) - BSA Free [NBP2-23558] - Endocrine alpha cells from diabetic mice stained with (1:500). Courtesy of Dr. Annette Plesner, University of British Columbia

Glucagon Antibody (4) - BSA Free [NBP2-23558] - BSA Free [NBP2-23558]

• Reactivity: Hu, Mu, Ma
• Applications: ELISA, IHC
• Clone: 4
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

GLP1 Antibody (4) - BSA Free Summary

• Immunogen: Synthetic GLP-1(7-17)
• Epitope: Free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide.
• Specificity: This antibody binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2% cross-reactivity with GLP-1(1-37), GLP-1(9-36)amide, human GIP and exendin-4. Cross-reacts approximately 1% with human GLP-2.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: GCG
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
• Application Notes: ELISA: NBP2-23558 binds free GLP-1(7-37) and free GLP-1(7-36) amide. Not recommended for use in sandwich ELISA. (1)

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 10mM Phosphate (pH 7.4) and 0.5M NaCl
• Preservative: 15mM Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Alternate Names for GLP1 Antibody (4) - BSA Free

• glicentin-related polypeptide
• GLP1
• GLP-1
• glucagon-like peptide 1
• GRPP

Background

Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for GLP1 Antibody (NBP2-23558)(2)

Publications using NBP2-23558

• Greenwood MP, Greenwood M, B�rez-L�pez S et al. Osmoadaptive GLP-1R signalling in hypothalamic neurones inhibits antidiuretic hormone synthesis and release Molecular metabolism 2023-02-10 [PMID: 36773648] (IHC, Rat)
• Tellez K, Hang Y, Gu X In vivo studies of glucagon secretion by human islets transplanted in mice Nat Metab 2020-07-23 [PMID: 32694729]

Bioinformatics

• Gene Symbol: GCG