GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody

Product Discontinued

GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody Summary

• Immunogen: The antiserum was produced against synthesized peptide derived from human GFRA4. The immunogen region is: Internal.
• Specificity: GFRA4 Antibody detects endogenous levels of total GFRA4 protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GFRA4
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Western Blot 1:500-1:1000
• Theoretical MW: 31.67 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody

• GDNF family receptor alpha 4
• GDNF family receptor alpha-4
• GDNF R alpha-4
• GDNF receptor alpha-4
• GDNFR-alpha-4
• GFR alpha4
• GFR alpha-4
• GFR receptor alpha 4
• GFRA4
• GFRa-4
• GFR-alpha-4
• Persephin receptor

Background

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRalpha-1 (previously designated GDNFR-alpha), GFRalpha-2 (also designated RETL2), GFRalpha-3 and GFRalpha-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRalpha-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GFRA4
• Entrez:
  • 64096(Human)
• Uniprot:
  • Q9GZZ7(Human)