GFI-1 Antibody [Allophycocyanin]

• Reactivity: Hu
• Applications: WB, CyTOF-ready, Flow
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Allophycocyanin

GFI-1 Antibody [Allophycocyanin] Summary

• Immunogen: E. coli-derived recombinant human GFI-1
  Pro2-Leu250
  Accession # Q99684
• Specificity: Detects human GFI-1 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: GFI1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for GFI-1 Antibody [Allophycocyanin]

• GFI1
• GFI-1
• growth factor independence-1
• growth factor independent 1 transcription repressor
• growth factor independent 1
• Growth factor independent protein 1
• Pal-1
• SCN2
• Zinc finger protein 163
• zinc finger protein Gfi-1
• ZNF163
• ZNF163FLJ94509

Background

GFI1 encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GFI1