GFI-1 Products

Description

GFI1 encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

Bioinformatics

Entrez	2672 Human
Uniprot	NM_005263 Human NP_001120687 Human NP_001120688 Human NP_005254 Human Q99684 Human
Product By Gene ID	2672
Alternate Names	GFI-1 growth factor independence-1 growth factor independent 1 transcription repressor growth factor independent 1 Growth factor independent protein 1 SCN2 Zinc finger protein 163 zinc finger protein Gfi-1 ZNF163FLJ94509

Research Areas for GFI-1

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Cell Cycle and Replication