GCN2 Antibody

Images

 
Western Blot: GCN2 Antibody [NB100-1593] - Detection of Human GCN2 on HeLa whole cell lysate using NB100-1593. GCN2 was also immunoprecipitated using another GCN2 Ab.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml
 

Independent Antibodies

 

Biological Strategies

     

Order Details

GCN2 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human GCN2 (eIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4) using the numbering given in entry NP_001013725.2 (GeneID 440275).
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
EIF2AK4
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:5000-1:15000
  • Immunoprecipitation 2-5 ug/mg lysate
Positive Control
GCN2 Lysate (NBL1-10178)
Publications
Read Publication using NB100-1593.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for GCN2 Antibody

  • EIF2AK4
  • eukaryotic translation initiation factor 2 alpha kinase 4
  • eukaryotic translation initiation factor 2-alpha kinase 4
  • GCN2
  • GCN2GCN2 eIF2alpha kinase
  • GCN2-like protein
  • KIAA1338EC 2.7.11.1

Background

GCN2 is a kinase that phosphorylates the alpha subunit of EIF2. GCN2 functions as a sensor of amino acid deficiency and modulates protein metabolism in response to cellular stress. GCN2 has also been reported to function in the regulation of lipid metabolism during amino acid deprivation. Alternate names for GCN2 include eukaryotic translation initiation factor 2-alpha kinase 4, GCN2-like protein, EIF2AK4, and KIAA1338.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GCN2 Antibody (NB100-1593)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for GCN2 Antibody (NB100-1593)

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Blogs on GCN2.

eIF2alpha - a regulator of global translation in response to cellular stress
Eukaryotic initiation factor 2 (eIF2) regulates global protein translation by binding to Met-tRNA and the 40S ribosome to form the pre-initiation complex. eIF2 is a heterotrimer consisting of alpha, beta, and gamma subunits. The 36kDA eIF2a subuni...  Read full blog post.

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Bioinformatics

Gene Symbol EIF2AK4
Entrez
Uniprot