Galactosylceramidase/GALC Antibody

Images

 
Western Blot: GALC Antibody [NBP2-16578] - Sample (30 ug of whole cell lysate) A: H1299 7. 5% SDS PAGE gel, diluted at 1:1000.
Immunohistochemistry-Paraffin: Galactosylceramidase/GALC Antibody [NBP2-16578] - Paraffin-embedded rat liver. Galactosylceramidase antibody diluted at 1:400.

Product Details

Summary
Reactivity Hu, Rt, MkSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.42 mg/ml

Order Details

Galactosylceramidase/GALC Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human Galactosylceramidase. The exact sequence is proprietary.
Localization
Lysosome
Predicted Species
Monkey (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GALC
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
77 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Expected cross reactivity based on sequence homology: Canine (87%), Rhesus Monkey (95%), Bovine (84%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.42 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Galactosylceramidase/GALC Antibody

  • EC 3.2.1.46
  • Galactocerebrosidase
  • Galactocerebroside beta-galactosidase
  • galactosylceramidase (Krabbe disease)
  • Galactosylceramidase
  • Galactosylceramide beta-galactosidase
  • Galactosylceraminidase
  • GALC
  • GALCERase

Background

This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol GALC
Entrez
Uniprot