GAK Antibody (706306)

Images

 
Western blot shows lysates of Daudi human Burkitt's lymphoma cell line and BJAB human Burkitt's lymphoma cell line. PVDF membrane was probed with 1 µg/mL of Mouse Anti-Human GAK Monoclonal Antibody (Catalog # MAB6918) ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clone
706306
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

GAK Antibody (706306) Summary

Immunogen
E. coli-derived recombinant human GAK
Phe258-Asp443
Accession # O14976
Specificity
Detects human GAK in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
GAK
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
Positive Control
GAK Lysate (NBP2-65752)
Publications
Read Publication using
MAB6918 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Sterile PBS to a final concentration of 0.5 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GAK Antibody (706306)

  • Auxillin 2
  • cyclin G associated kinase
  • cyclin-G-associated kinase
  • EC 2.7.11.1
  • FLJ16629
  • FLJ40395
  • GAK
  • MGC99654

Background

Cyclin G-associated kinase (GAK), also known as Auxilin 2, is an approximately 140 kDa widely expressed protein that associates with CDK5. GAK promotes microtubule growth during mitotic spindle assembly and is required for centrosome maturation, chromosome congression, and mitotic progression. It also regulates the assembly and intracellular trafficking of clathrin-coated vesicles. GAK contains a Ser/Thr protein kinase domain (aa 40-314), a phosphatase tensin/auxilin domain (aa 399-566), a PTEN C2 domain (aa 570-708), and a J domain (aa 1247-1311). Within aa 258-443, human GAK shares 88% aa sequence identity with mouse and rat GAK.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GAK Antibody (MAB6918)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol GAK
Entrez
Uniprot