GADD45 alpha Antibody [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 532

GADD45 alpha Antibody [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human GADD45α
  Met1-Arg165
  Accession # P24522
• Specificity: Detects human GADD45 alpha in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GADD45 alpha Antibody [Alexa Fluor® 532]

• DDIT-1
• DDIT1growth arrest and DNA damage-inducible protein GADD45 alpha
• DNA damage-inducible transcript 1 protein
• DNA damage-inducible transcript-1
• GADD45 alpha
• GADD45a
• GADD45DNA-damage-inducible transcript 1
• growth arrest and DNA-damage-inducible 45 alpha
• growth arrest and DNA-damage-inducible, alpha

Background

GADD45 alpha (Growth arrest and DNA damage-inducible protein 45 alpha) is a 19 kDa member of the GADD45 family of proteins. It is ubiquitously expressed, and induced by DNA damage. Upon induction, GADD45 alpha binds to PCNA, stimulates DNA excision repair, and initiates G2 cell cycle arrest. Human GADD45 alpha is 165 amino acids (aa) in length. It is reported to dimerize with GADD45-beta and -gamma , and to homo-dimerize, -trimerize and -tetramerize via residues 33‑61 and 133‑165. There is one splice variant that shows a Ser substitution for aa 14‑49. GADD45 alpha is 55% aa identical to GADD45-beta and -gamma , and shares 94% aa identity with mouse GADD45 alpha .

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.