GABA-B R2 Antibody (SR1039) - BSA Free

Western Blot: GABA-B R2 Antibody (SR1039) [NBP3-21952] - Western blot analysis using NBP3-21952 in SH-SY5Y cell lysate.

• Reactivity: Hu, Mu, Rt
• Applications: WB, Flow, ICC/IF, IHC
• Clone: SR1039
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

GABA-B R2 Antibody (SR1039) - BSA Free Summary

• Description: Novus Biologicals Rabbit GABA-B R2 Antibody (SR1039) - BSA Free (NBP3-21952) is a recombinant monoclonal antibody validated for use in IHC, WB, Flow and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: A synthesized peptide derived from human GABA-B R2 (Uniprot #: O75899)
• Specificity: Detects endogenous levels of total GABA-B R2
• Source: HEK293
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: GABBR2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:40
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Western Blot 1:500-1:1000
• Theoretical MW: 106 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, pH 7.4, 150mM NaCl, 50% glycerol.
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for GABA-B R2 Antibody (SR1039) - BSA Free

• G protein-coupled receptor 51
• GABA B R2
• GABABR2
• GABA-BR2
• GABA-B-R2
• GABABR2GABA-B receptor 2
• GABBR2
• gamma-aminobutyric acid (GABA) B receptor, 2
• gamma-aminobutyric acid type B receptor subunit 2
• gb2
• GPR51
• GPR51GABA-B receptor, R2 subunit
• GPRC3B
• GPRC3BFLJ36928
• G-protein coupled receptor 51
• HG20HRIHFB2099

Background

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GABBR2