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VC004). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to dorsal horn. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
HAF019). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
Non-specific interaction with the 230 kDa Simple Western standard may be seen with this antibody." class="big_lightbox" target="_blank">
HAF008). A specific band was detected for GABABR2 at approximately 106 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neurons and neuronal processes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal processes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
VC003). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal processes. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents." class="big_lightbox" target="_blank">
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).
![Immunohistochemistry GABA-B R2 Antibody [Unconjugated] - N-Terminus](http://images.novusbio.com/images/antibody/GABA_B_R2_AF1188_Immunohistochemistry_23164.jpg)
![Western Blot GABA-B R2 Antibody (2605C) [Unconjugated]](http://images.novusbio.com/images/antibody/GABA_B_R2_MAB10456_Western_Blot_24222.jpg)
![Simple Western GABA-B R2 Antibody [Unconjugated] - N-Terminus](http://images.novusbio.com/images/antibody/af1188_rat-gaba-b-r2-affinity-purified-polyclonal-ab-simple-western-13720201031.jpg)
![Immunohistochemistry GABA-B R2 Antibody (2605C) [Unconjugated]](http://images.novusbio.com/images/antibody/GABA_B_R2_MAB10456_Immunohistochemistry_24280.jpg)
![Immunohistochemistry GABA-B R2 Antibody (2605C) [Unconjugated]](http://images.novusbio.com/images/antibody/GABA_B_R2_MAB10456_Immunohistochemistry_24281.jpg)
![Immunohistochemistry GABA-B R2 Antibody (2605C) [Unconjugated]](http://images.novusbio.com/images/antibody/GABA_B_R2_MAB10456_Immunohistochemistry_24282.jpg)
![Simple Western GABA-B R2 Antibody (2605C) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/mab10456_human-mouse-rat-gaba-b-r2-mab-clone-2605c-simple-western-58202114729.jpg)
