GABA-A R beta 3 Antibody (N87/25) [Alexa Fluor® 750]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF, IHC, MA
• Clone: N87/25
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

GABA-A R beta 3 Antibody (N87/25) [Alexa Fluor® 750] Summary

• Immunogen: Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta 3
• Localization: Cell Membrane , Cell Junction , Synapse , Postsynaptic Cell Membrane
• Specificity: Detects approx 55kDa. No cross-reactivity against GABA-A-R-Beta 2 or -Beta1.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: GABRB3
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Microarray
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for GABA-A R beta 3 Antibody (N87/25) [Alexa Fluor® 750]

• ECA5
• GABA A R beta 3
• GABA(A) receptor beta-3 subunit
• GABA(A) receptor subunit beta-3
• GABAA receptor beta-3 subunit
• GABA-alpha receptor beta-2 subunit
• GABAAR beta 3
• GABAARb3
• GABRB3
• gamma-aminobutyric acid (GABA) A receptor, beta 3
• gamma-aminobutyric acid receptor subunit beta-3
• MGC9051

Background

The GABRB3 gene encodes a member of the ligand-gated ionic channel family. The encoded protein, GABA A Receptor beta 3, is one of at least 13 distinct subunits of a multisubunit chloride channel that serves as the receptor for gamma-aminobutyric acid, the major inhibitory transmitter of the nervous system. GABRB3 is located on the long arm of chromosome 15 in a cluster with two genes encoding related subunits of the family. Mutations in the GABA A Receptor beta 3 gene may be associated with the pathogenesis of Angelman syndrome, Prader-Willi syndrome, and autism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GABRB3