Frizzled-5 Antibody [CoraFluor™ 1]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: CoraFluor 1

Frizzled-5 Antibody [CoraFluor™ 1] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Frizzled‑5
  Ala27-Pro167
  Accession # AAC50385
• Specificity: Detects human Frizzled-5 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse (rm) Frizzled-1, rmFrizzled-2, rmFrizzled-3, rmFrizzled-6, rmFrizzled-7, and rmFrizzled-8 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: FZD5
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Antigen Affinity-purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Frizzled-5 Antibody [CoraFluor™ 1]

• C2orf31
• chromosome 2 open reading frame 31
• DKFZP434E2135
• frizzled (Drosophila) homolog 5
• frizzled homolog 5 (Drosophila)
• Frizzled5
• Frizzled-5
• Frz-5
• FZ-5
• FZD5
• fzE5
• HFZ5
• MGC129692
• seven-transmembrane receptor frizzled-5
• Wnt receptor

Background

FZD5 is a Frizzled Receptor that mediates Wnt signaling. FZD5 is associated with limb bud and bone marrow stem cell development. FZD5 contributes to the activated state of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Recently, FZD5 has been implicated in melanoma metastasis through the Wnt5a and PKC pathway. FZD5 has been reported to be expressed in fetal kidney, fetal and adult liver, fetal lung, and adult pancreas. ESTs have been isolated from bone, liver/spleen, placenta, and prostate libraries. FZD5 was cloned from a retina cDNA library.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: FZD5