FPRL1/FPR2 Antibody [FITC]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
FITC

FPRL1/FPR2 Antibody [FITC] Summary

Immunogen
Synthetic peptide made to the 2nd extracellular loop of the human FPRL1 protein (between residues 300-350) [UniProt P25090]
Localization
Cell membrane; Multi-pass membrane protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FPR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunohistochemistry 1:300
  • Immunohistochemistry-Paraffin 1:300
Application Notes
This FPRL1 antibody is useful for Western Blot, Immunocytochemistry/Immunofluorescence, and Immunohistochemistry paraffin embedded sections. In Western Blot, a band is seen ~38 kDa representing FPRL1. In ICC/IF, plasma membrane staining was observed in Raw264.7 cells. In IHC-P, staining was also observed in the plasma membrane of human kidney cancer tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Customers have reported success in IF on FFPE mouse kidney tissue, following microwave antigen retrieval. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24086560)

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and mouse. Rat reactivity reported in scientific literature (PMID: 24086560)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for FPRL1/FPR2 Antibody [FITC]

  • ALXR
  • FMLP-R-I
  • FMLP-R-II
  • FMLPX
  • formyl peptide receptor 2
  • Formyl peptide receptor-like 1RFP
  • FPR2
  • FPR2A
  • FPRH1FMLP-related receptor I
  • FPRL1
  • FPRL1LXA4 receptor
  • HM63
  • HM63FPRH2
  • lipoxin A4 receptor (formyl peptide receptor related)
  • Lipoxin A4 receptor
  • LXA4 Receptor
  • LXA4RFMLP-R-I
  • N-formyl peptide receptor 2
  • RFP

Background

FPRL1 (formyl peptide receptor-like-1 or N-formyl peptide receptor 2) is a multi-pass membrane protein receptor belonging to the GPCR1 family and is expressed abundantly in lungs and neutrophils. Among human FPRs and its variants (FPRL1/FPR-like 1 and FPRL2/FPR-like 2), FPRL1 is less efficiently activated by N-fMLP (N-formylmethionylleucylphenylalanine) than FPR and certain agonists which bind FPRL1 with high affinity includes lipoxin A4 eicosanoid, annexin 1, uPAR, the V3 region of the HIV-1 envelope glycoprotein gp120, the acute-phase protein SAA, the 42-amino-acid form of beta-amyloid, human prion peptide, and cathelicidin LL-37. FPRL1 binding to its agonists triggers the activation of intracellular signaling molecules including calcium, PKC isoforms, phospholipases A2 and D, and MAPKs/p38MAPK. FPRL1 activation may result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as leukotriene B4. Expression of FPR1, FPRL1, and FPRL2 has recently been documented to enhance invasive potential of melanoma cells. Moreover, FPRL1 interacts with amyloid beta peptides is implicated in phagocyte attraction to sites of amyloid plaques in Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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WB Video Protocol

FAQs for FPRL1/FPR2 Antibody (NLS1878F). (Showing 1 - 1 of 1 FAQ).

  1. I am looking for an FPRL1 antibody that is reactive to mouse only. Does Novus have the antibody in question?
    • To answer your question, unfortunately all our FPRL1 antibodies are polyclonal and would detect both mouse and human formyl peptide receptor-like-1 and we do not have any mouse monoclonal antibody for it.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol FPR2
Entrez