FPRL1/FPR2 Antibody [DyLight 650]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 650

FPRL1/FPR2 Antibody [DyLight 650] Summary

Immunogen
Synthetic peptide made to the 2nd extracellular loop of the human FPRL1 protein (between residues 300-350) [UniProt P25090]
Localization
Cell membrane; Multi-pass membrane protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FPR2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
  • Immunocytochemistry/Immunofluorescence 1:20-1:75
  • Immunohistochemistry 1:300
  • Immunohistochemistry-Paraffin 1:300
Application Notes
This FPRL1 antibody is useful for Western Blot, Immunocytochemistry/Immunofluorescence, and Immunohistochemistry paraffin embedded sections. In Western Blot, a band is seen ~38 kDa representing FPRL1. In ICC/IF, plasma membrane staining was observed in Raw264.7 cells. In IHC-P, staining was also observed in the plasma membrane of human kidney cancer tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. Customers have reported success in IF on FFPE mouse kidney tissue, following microwave antigen retrieval. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24086560)

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and mouse. Rat reactivity reported in scientific literature (PMID: 24086560)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for FPRL1/FPR2 Antibody [DyLight 650]

  • ALXR
  • FMLP-R-I
  • FMLP-R-II
  • FMLPX
  • formyl peptide receptor 2
  • Formyl peptide receptor-like 1RFP
  • FPR2
  • FPR2A
  • FPRH1FMLP-related receptor I
  • FPRL1
  • FPRL1LXA4 receptor
  • HM63
  • HM63FPRH2
  • lipoxin A4 receptor (formyl peptide receptor related)
  • Lipoxin A4 receptor
  • LXA4 Receptor
  • LXA4RFMLP-R-I
  • N-formyl peptide receptor 2
  • RFP

Background

Formyl peptide receptor-like receptor 1 (FPRL1), a chemo-attractant receptor also called Lipoxin A4 Receptor (LXA4R), functions as a component of the inflammatory response. The stimulation of FPRL1 results in neutrophil activation and desensitization of chemokine receptors in monocytes (PubMed ID: 11015447). The FPRL1 receptor is up-regulated by interleukin-1 in normal human synovial fibroblasts. The immunodeficiency virus type 1 (HIV-1) envelope protein gp41 can activate the innate host immune cells through FPRL1 and induces directional migration and calcium mobilization in human monocytes and neutrophils. FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. Expressed sequence tags (ESTs) for FPRL1 have been isolated from blood, leukocyte, lung, and placenta libraries. Recently, FPRL1 has been implicated in Alzheimers Disease. Note that Formyl peptide receptor-like receptor 1 (FPRL1) and Formyl peptide receptor 2 (FPR2) are the same, but FPR2 is distinct from FPRL2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for FPRL1/FPR2 Antibody (NLS1878C). (Showing 1 - 1 of 1 FAQ).

  1. I am looking for an FPRL1 antibody that is reactive to mouse only. Does Novus have the antibody in question?
    • To answer your question, unfortunately all our FPRL1 antibodies are polyclonal and would detect both mouse and human formyl peptide receptor-like-1 and we do not have any mouse monoclonal antibody for it.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol FPR2
Entrez