FLIP Antibody

Product Discontinued

FLIP Antibody Summary

• Immunogen: Rabbit anti-FLIP (CT) polyclonal antibody was raised against a peptide corresponding to amino acids 191 to 209 at C-terminus of human FLIPdelta/FLIPs form2.
• Specificity: Rabbit Polyclonal to FLIPs
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CFLAR
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000
• Application Notes: This antibody can be used for detection of FLIP by Western blot at 1:1000 dilution. Jurkat cell lysate can be used as positive control and 35 kDa and 25 kDa bands can be detected. This antibody recognizes human and murine FLIPg and FLIPd but not FLIPa and FLIPb.

Reactivity Notes

This antibody is reactive against Human, Mouse

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for FLIP Antibody

• CASHFADD-like antiapoptotic molecule 1
• CASP8 and FADD-like apoptosis regulator
• CASP8AP1
• Caspase homolog
• Caspase-eight-related protein
• Caspase-like apoptosis regulatory protein
• caspase-related inducer of apoptosis
• CASPER
• CasperFLAME1
• Cellular FLICE-like inhibitory protein
• CFLAR
• c-FLIPR
• c-FLIPS
• CLARPMACH-related inducer of toxicity
• FADD-like apoptotic molecule
• FLAME
• FLAME-1
• FLIP
• I-FLICE
• I-FLICEMRITc-FLIPFLIPc-FLIPL
• Inhibitor of FLICE
• usurpin beta
• Usurpin

Background

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)-containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and c-FLIPs, respectively1,2. The human FLIPs were also cloned by several labs independently and termed Casper, I-FLICE, FLAME-1, CASH, CLARP and usurpin3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CFLAR