Western Blot: FKBP51/FKBP5 Antibody [NB100-68240] - Normalized expression of TGF-b mRNA in WT, EV-, or FKBP51/FKBP5-stably transfected melanoma cells. WT sample expression 1/4 1. (n 1/4). Western blot assay of TGF-b ...read more
Immunohistochemistry: FKBP51/FKBP5 Antibody [NB100-68240] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-FKBP5/FKBP51 used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB
Independent Antibodies: Western Blot: FKBP51/FKBP5 Antibody [NB100-68240] - Western Blot and Immunoprecipitation: FKBP5/FKBP51 Antibody NB100-68240 - Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for ...read more
Genetic Strategies: Knockdown Validated: FKBP51/FKBP5 Antibody [NB100-68240] - FKBP51/FKBP5 modulates EMT hallmarks. FKBP51/FKBP5 silencing of SAN melanoma cells decreases TGF-b and TbRIII expression. Normalized ...read more
The immunogen recognized by this antibody maps to a region between residue 407 and 457 of human FK506 binding protein 5 (51 kDa FK506-binding protein) using the numbering given in entry NP_004108.1 (GeneID 2289).
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Immunogen affinity purified
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Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID:28978117).
51 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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