Filamin B Antibody

Product Discontinued

Filamin B Antibody Summary

• Immunogen: Peptide with sequence KITDDSRRCSQVK corresponding to internal region according to NP_001157789.1, NP_001157790.1, NP_001157791.1.
• Specificity: This antibody is expected to recognise all reported isoforms (NP_001448.2; NP_001157789.1; NP_001157790.1; NP_001157791.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: FLNB
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
• Application Notes: WB: Preliminary experiments in human brain, mouse brain and rat brain lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Filamin B Antibody

• ABP-278filamin B, beta (actin binding protein 278)
• ABP-280 homolog
• actin binding protein 278
• Actin-binding-like protein
• AOI
• beta-filamin
• DKFZp686O033
• FH1
• filamin B, beta
• Filamin homolog 1
• filamin-3
• filamin-B
• FLN1L
• FLN3
• FLN-B
• Larsen syndrome 1 (autosomal dominant)
• LRS1
• SCT
• TABPABP-280
• TAPDKFZp686A1668
• Thyroid autoantigen
• Truncated ABP
• Truncated actin-binding protein

Background

FLNB connects cell membrane constituents to the actin cytoskeleton. It may promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Filamin B Antibody (NB100-53813)(1)

Publication using NB100-53813

• Takafuta T, Wu G, Murphy GF, Shapiro SS. Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha. J Biol Chem 1998-07-10 [PMID: 9651345]

Bioinformatics

• Gene Symbol: FLNB
• Entrez:
  • 2317(Human)
  • 286940(Mouse)
  • 306204(Rat)
• Uniprot:
  • NP_001448.2(Human)