FEZ1 Antibody

Images

 
Western Blot: FEZ1 Antibody [NBP1-76395] - Analysis of SAPAP2 in Raji cell lysate with SAPAP2 antibody at (A) 0.5 and (B) 1 ug/mL.
Western Blot: FEZ1 Antibody [NBP1-76395] - SK-N-SH cell lysate with FEZ1 antibody at 1 ug/mL in the (A) presence and (B) absence of blocking peptide.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

FEZ1 Antibody Summary

Immunogen
Antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FEZ1. The immunogen is located within amino acids 270 - 320 of FEZ1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
FEZ1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
Application Notes
FEZ1 antibody can be used for the detection of FEZ1 by Western blot at 1 mg/ml.
Theoretical MW
46 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Control Peptide
FEZ1 Peptide (NBP1-76395PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for FEZ1 Antibody

  • fasciculation and elongation protein zeta 1 (zygin I)
  • fasciculation and elongation protein zeta-1
  • Zygin I
  • zygin-1

Background

Similar to its C. elegans homolog UNC-76, mammalian FEZ1, an abundant membrane protein and protein kinase C (PKC)-Z substrate, is involved in axonal guidance. Following phosphorylation by PKC-Z, FEZ1 translocates from the plasma membrane to the cytoplasm. FEZ1 is then able to interact with a number of proteins involved in axonal outgrowth and cellular transport such as DISC1, a candidate gene for schizophrenia, as well as kinesin-1, a microtubule-based motor protein. FEZ1 also interacts with proteins involved in transcriptional regulation and chromatin remodeling, suggesting that FEZ1 may have nuclear regulatory functions in addition to those for neuronal development. At least two distinct isoforms of FEZ1 are known to exist. Despite its predicted molecular weight, FEZ1 will often run at higher molecular weight in SDS-PAGE.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol FEZ1
Uniprot