FCRL1/FcRH1 Antibody (282415) [Alexa Fluor® 750]


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Product Details

Reactivity HuSpecies Glossary
Applications Flow
Alexa Fluor 750
Please see the vial label for concentration. If unlisted please contact technical services.

Order Details

FCRL1/FcRH1 Antibody (282415) [Alexa Fluor® 750] Summary

Mouse myeloma cell line NS0-derived recombinant human FCRL1/FcRH1
Accession # Q96LA6
Detects human FCRL1/FcRH1 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) FCRL2, 3, 4, or 5 is observed.
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  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FCRL1/FcRH1 Antibody (282415) [Alexa Fluor® 750]

  • BXMH1
  • CD307a antigen
  • CD307a
  • Fc receptor homolog 1
  • Fc receptor-like 1
  • FcRH1
  • FCRH1DKFZp667O1421
  • FCRL1
  • FcR-like protein 1
  • hIFGP1
  • IFGP family protein 1
  • IFGP1
  • IFGP1Fc receptor-like protein 1
  • Immune receptor translocation-associated protein 5
  • IRTA5
  • IRTA5immunoglobulin superfamily Fc receptor, gp42


Fc Receptor-Like 1 (FCRL1), also known as FcRH1, and IRTA5, is an approximately 50 kDa protein with sequence homology to classical Fc receptors. The type 1 transmembrane FCRL proteins contain from three to nine immunoglobulin-like domains. They are differentially expressed within the B cell lineage and can either promote or inhibit B cell proliferation and activation (1, 2). According to R&D Systems testing, FCRL1 binds to purified human IgG. Mature human FCRL1 consists of a 291 amino acid (aa) extracellular domain (ECD) with three Ig-like domains, a 21 aa transmembrane segment, and a 101 aa cytoplasmic domain with two immunotyrosine activation motifs (ITIMs) (3, 4). A charged glutamic acid within the transmembrane segment may mediate association with other signaling proteins. Alternative splicing may generate an isoform that lacks the transmembrane segment and an isoform that largely consists of the first two Ig-like domains (5). Mouse FCRL1 contains only two Ig-like domains, but it shares 62% aa sequence identity with homologous regions of the human FCRL1 ECD. FCRL1 is expressed on pre-B cells and naive B cells (6, 7). It is down‑regulated upon B cell activation but up‑regulated on memory B cells (6, 8). FCRL1 is expressed on many B cell lymphoma and leukemia tumor cells with the exception of B cell acute lymphoblastic leukemia (9‑11). Antibody crosslinking of FCRL1 triggers its tyrosine phosphorylation and augments B cell proliferation induced by the B cell receptor (6).
  1. Davis, R.S. et al. (2007) Annu. Rev. Immunol. 25:525.
  2. Maltais, L.J. et al. (2006) Nat. Immunol. 7:431.
  3. Miller, I. et al. (2002) Blood 99:2662.
  4. Davis, R.S. et al. (2001) Proc. Natl. Acad. Sci. 98:9772.
  5. Accession # Q96LA6.
  6. Leu, C.-M. et al. (2005) Blood 105:1121.
  7. Li, F.J. et al. (2008) Blood 112:179.
  8. Polson, A.G. et al. (2006) Int. Immunol. 18:1363.
  9. Du, X. et al. (2008) Blood 111:338.
  10. Kazemi, T. et al. (2008) Int. J. Cancer 123:2113.
  11. Kazemi, T. et al. (2009) Cancer Immunol. Immunother. 58:989.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol FCRL1