FCRLB/FCRY Antibody (454217) [Unconjugated]

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Daudi human Burkitt's lymphoma cell line was stained with Mouse Anti-Human FCRLB/FCRY Monoclonal Antibody (Catalog # MAB4705, filled histogram) or isotype control antibody (Catalog # MAB0041, open histogram), followed ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, CyTOF-ready, Flow
Clone
454217
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

FCRLB/FCRY Antibody (454217) [Unconjugated] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human FCRLB/FCRY
Ala18-Ser426
Accession # Q6BAA4
Specificity
Detects human FCRLB/FCRY in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
FCRLB
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for FCRLB/FCRY Antibody (454217) [Unconjugated]

  • Fc receptor homolog expressed in B cells protein 2
  • Fc receptor like 2
  • Fc receptor-like and mucin-like 2
  • Fc receptor-like and mucin-like protein 2
  • Fc receptor-like B
  • Fc receptor-like protein 2
  • Fc receptor-related protein Y
  • FcRL2
  • FCRL2FCRLM2
  • FCRLB
  • FCRLM2
  • FCRLY
  • FCRY
  • FLJ31052
  • FREB2
  • FREB-2
  • FREB-2FcRY
  • RP11-474I16.6

Background

FCRLB, also known as FCRL2, FCRY, and FREB2, is a 60 kDa protein with sequence homology to classical Fc receptors. There are at least six type 1 transmembrane FCRL proteins and two that lack transmembrane segments. Each family member contains between three and nine immunoglobulin-like domains. FCRL proteins are differentially expressed within the B cell lineage and can either promote or inhibit B cell proliferation and activation (1, 2). According to R&D Systems testing, FCRLB binds to purified human IgG with high affinity. Human FCRLB shares 82% and 85% amino acid sequence identity with mouse and rat FCRLB, respectively. It contains a putative signal peptide, three immunoglobulin-like domains, and a mucin-like stalk that is rich in Pro, Ser, and Thr residues (1‑3). The stalk region also contains di-Leu motifs and an unpaired cysteine (1‑3). Alternative splicing generates isoforms with deletions in the putative signal peptide and substitutions and/or truncations in the third Ig-like domain (3). When expressed in transfectants, FCRLB is not secreted but shows a diffuse intracellular localization (3, 4). FCRLB is expressed at a low level in placenta and in B lineage cells of the germinal center (3, 4). It is upregulated in B cells by BAFF and LPS (5). Among non-hematopoietic cells, FCRLB is expressed in fibroblasts, melanocytes, and melanoma (3, 5). It is preferentially expressed in nonproliferating cells and at the onset of apoptosis (4, 5).

  1. Davis, R.S. (2007) Annu. Rev. Immunol. 25:525.
  2. Maltais, L.J. et al. (2006) Nat. Immunol. 7:431.
  3. Chikaev, N.A. et al. (2005) Genomics 85:264.
  4. Wilson, T.J. and M. Colonna (2005) Genes Immun. 6:341.
  5. Masuda, K. et al. (2005) Gene 363:32.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol FCRLB
Uniprot