FBXW7/Cdc4 Products

Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.

Bioinformatics

Entrez	55294 Human
Uniprot	NP_060785.2 Human
Product By Gene ID	55294
Alternate Names	AGO AGOFBXO30 Archipelago Homolog archipelago, Drosophila, homolog of Cdc4 CDC4FLJ16457 F-box and WD repeat domain containing 7 F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) F-box and WD-40 domain-containing protein 7 F-box protein FBW7 F-box protein FBX30 F-box protein SEL-10 F-box/WD repeat-containing protein 7 FBW6 Fbw7 FBW7hCdc4 FBX30 FBX30FLJ11071 FBXO30 FBXW6 FBXW7 hAgo homolog of C elegans sel-10 SCF(Fbw7) SEL10 SEL-10DKFZp686F23254 SEL10FBW6