Factor XII Antibody Summary
A human Factor XII.
Recognizes human Factor XII.
Immunogen affinity purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
10mM HEPES (pH 7.4), 0.15M NaCl and 50% Glycerol
Immunogen affinity purified
- Western Blot 1:1000 - 1:10000
- Immunohistochemistry-Paraffin 5 ug/ml
Alternate Names for Factor XII Antibody
- beta-factor XIIa part 1
- coagulation factor XII (Hageman factor)
- coagulation factor XII
- coagulation factor XIIa heavy chain
- coagulation factor XIIa light chain
- EC 3.4.21
- EC 126.96.36.199
- HAF beta-factor XIIa part 2
- Hageman factor
Coagulation factor XII circulates in blood as a zymogen. This single chain zymogen is converted to a two chain serine protease with an heavy chain (alpha factor XIIa) and a light chain. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any clinical symptoms and the sole effect is that whole blood clotting time is prolonged.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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