Factor XII Products

Antibodies
Factor XII Antibody
Factor XII Antibody
NBP1-94203
Species: Hu, Mu, Rt, Pm
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Factor XII Antibody
Factor XII Antibody
NBP1-86518
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Factor XII Antibody
Factor XII Antibody
NBP1-50262
Species: Hu
Applications: WB, IHC-P
Host: Goat Polyclonal
ELISA Kits
Factor XII ELISA Kit [HRP]
Factor XII ELISA Kit [HRP]
KA1037
Species: Hu
Lysates
Factor XII Overexpression Lys ...
Factor XII Overexpression Lysate (...
H00002161-T01
Applications: WB
Proteins
Factor XII Recombinant Protei ...
Factor XII Recombinant Protein Ant...
NBP1-86518PEP
Species: Hu
Applications: AC

Description

Coagulation factor XII, also called Hageman factor, circulates in blood as a zymogen. This single chain zymogen is activated by contact with negatively charged polyanions,to form a two chain serine protease containing alpha factor XIIa. The heavy chain contains two fibronectin type domains, two epidermal growth factor (EGF) like domains, a kringle domain and a proline rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta factor XIIa light chain and the alpha factor XIIa light chain becomes beta factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha factor XIIa and then to beta factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in Factor XII gene do not cause any clinical symptoms and the sole effect is that whole blood clotting time is prolonged.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 2161
Alternate Names
  • HAF
  • F12
  • EC 3.4.21
  • HAEX
  • coagulation factor XIIa light chain
  • HAE3
  • coagulation factor XIIa heavy chain
  • EC 3.4.21.38
  • coagulation factor XII
  • Hageman factor
  • HAF beta-factor XIIa part 2
  • beta-factor XIIa part 1
  • coagulation factor XII (Hageman factor)

Bioinformatics Tool for Factor XII

Discover related pathways, diseases and genes to Factor XII. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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