ETV5/ERM Antibody (654404) [Alexa Fluor® 647]

• Applications: ICC/IF
• Clone: 654404
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

ETV5/ERM Antibody (654404) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human ETV5
  Asn119-Ser223
  Accession # P41161
• Specificity: Detects human ETV5 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) ETV1 or rhETV2 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

ETS translocation variant 5 (ETV5), also known as ERM, is an approximately 70 kDa member of the ETS transcription factor family. The expression of ETV5 in Sertoli, granulosa, and cumulus cells is important for the ability of these cells to support spermatogonia stem cell and oocyte development. ETV5 is upregulated at the invasive front of various carcinomas, and it plays a role in tumor cell invasiveness. It is a target of chromosomal translocation in prostate cancer and forms a fusion protein with TMPRSS2. It is also required for branching morphogenesis during early kidney development. ETV5 contains a single Ets DNA-binding domain (aa 367-452). Within aa 119-223, human ETV5 shares 92% aa sequence identity with mouse and rat ETV5.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.